{"entity":{"id":"radiogenomics","kind":"technology","name":"Radiogenomics: predicting radiation sensitivity from genes","aka":[],"tldr":"Using a tumour's gene expression or a patient's inherited variants to predict who needs more dose, who needs less, and who is at risk of severe side effects.","summary":"Two strands share the name. Tumour radiogenomics builds signatures such as the radiosensitivity index and the genomic-adjusted radiation dose that estimate how sensitive a tumour is and propose a personalised dose; prospective trials are beginning to test dose adjustment on these scores. Patient radiogenomics looks for inherited variants that predict normal-tissue toxicity, through consortia such as REQUITE and the Radiogenomics Consortium; effect sizes have been modest so far. Both aim to replace one-dose-fits-all prescriptions with dose tailored to biology.","status":"emerging","asOf":"2026-09-16","links":[{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/Radiogenomics"}],"tags":["radiation-wave1"],"related":[],"cancers":[],"sections":["radiation"],"technologies":["radiomics","imrt-igrt"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["alpha-beta-ratio"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"principle":"Gene expression or germline variants correlate with tumour or normal-tissue radiosensitivity and can guide dose prescription.","strengths":["Path to personalised dose","Uses existing sequencing","Large consortia data"],"limitations":["Prospective validation still limited","Small effect sizes for toxicity variants","Signatures differ across cancers"],"since":2009},"route":"/technologies/radiogenomics/","neighbours":{"section":[{"id":"radiation","kind":"section","name":"Radiation Therapy","route":"/fronts/radiation/"}],"technology":[{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"},{"id":"radiomics","kind":"technology","name":"Radiomics","route":"/technologies/radiomics/"}],"term":[{"id":"alpha-beta-ratio","kind":"term","name":"Alpha/beta ratio","route":"/terms/alpha-beta-ratio/"}]}}