{"entity":{"id":"raf1","kind":"target","name":"CRAF (RAF1)","aka":[],"tldr":"CRAF is BRAF's sibling in the growth-signal relay; sorafenib and regorafenib were designed against it, and it is the route by which RAS-mutant tumours escape BRAF-only drugs.","summary":"RAF1 (CRAF) is one of three RAF kinases that pass the signal from RAS to MEK. Sorafenib was originally developed as a CRAF inhibitor before its VEGF receptor activity explained its clinical effect, and regorafenib shares that profile. CRAF matters clinically because RAS-mutant and BRAF-inhibitor-treated tumours signal through CRAF dimers, the basis for pan-RAF inhibitors now in trials.","asOf":"2026-09-04","wikipedia":"https://en.wikipedia.org/wiki/C-Raf","links":[{"label":"UniProt P04049: RAF1","url":"https://www.uniprot.org/uniprotkb/P04049/entry"},{"label":"HGNC:9829 RAF1","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9829"},{"label":"ChEMBL target CHEMBL1906","url":"https://www.ebi.ac.uk/chembl/explore/target/CHEMBL1906"}],"tags":[],"related":["braf","mek"],"cancers":["hcc","rcc","colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":["sorafenib","regorafenib"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"symbol":"RAF1","biology":"Activated by RAS-GTP at the membrane and by dimerisation; it also has kinase-independent roles in blocking apoptosis.","whereFound":["All tissues","Drives MAPK signalling in RAS-mutant tumours and in resistance to BRAF inhibitors"],"targetClass":"kinase","prevalence":[]},"route":"/targets/raf1/","neighbours":{"target":[{"id":"braf","kind":"target","name":"BRAF","route":"/targets/braf/"},{"id":"mek","kind":"target","name":"MEK1/2","route":"/targets/mek/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"},{"id":"rcc","kind":"cancer","name":"Renal cell carcinoma","route":"/cancers/rcc/"}],"drug":[{"id":"regorafenib","kind":"drug","name":"Regorafenib","route":"/drugs/regorafenib/"},{"id":"sorafenib","kind":"drug","name":"Sorafenib","route":"/drugs/sorafenib/"}]}}