{"entity":{"id":"ranbp2","kind":"target","name":"RANBP2","aka":["RAN binding protein 2","E3 SUMO-protein ligase RanBP2","NUP358","ADANE","ANE1"],"tldr":"RANBP2 (E3 SUMO-protein ligase RanBP2) is an enzyme. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Lung cancer, Hepatocellular carcinoma, Renal cell carcinoma and 5 more.","summary":"E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Binds single-stranded RNA (in vitro).\n\nOpen Targets scores its association with cancer at 0.77 (direct and indirect evidence; datatypes literature 0.85, affected pathway 0.76, genetic association 0.10, somatic mutation 0.94). IntOGen calls it a driver in 7 cohorts (1 activating, 5 loss-of-function), covering Renal Clear Cell Carcinoma, Hepatocellular Carcinoma, Lung Squamous Cell Carcinoma, Neuroblastoma, Paraganglioma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:9848","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9848"},{"label":"UniProt P49792","url":"https://www.uniprot.org/uniprotkb/P49792/entry"},{"label":"NCBI Gene 5903","url":"https://www.ncbi.nlm.nih.gov/gene/5903"},{"label":"Ensembl ENSG00000153201","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000153201"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["lung-cancer","hcc","rcc","pheochromocytoma-paraganglioma","skin-cancer","breast-cancer","nsclc","clear-cell-rcc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 5 cohorts; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"RANBP2","role":["oncogene-driver","tumour-suppressor","fusion-partner"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:9848","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9848","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P49792","url":"https://www.uniprot.org/uniprotkb/P49792/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000153201","url":"https://platform.opentargets.org/target/ENSG00000153201/associations","note":"association with cancer (MONDO_0004992) 0.77; per-cancer scores at or above 0.5: melanoma 0.52, skin cancer 0.55, breast cancer 0.52, lung cancer 0.59 (GraphQL API, CC0)"},{"label":"IntOGen RANBP2","url":"https://www.intogen.org/search?gene=RANBP2","note":"driver in 7 cohorts (Act 1, LoF 5); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:9848","ensembl":"ENSG00000153201","uniprot":"P49792","entrez":"5903","biology":"E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Binds single-stranded RNA (in vitro). May bind DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Location: Nucleus; Nucleus membrane; Nucleus, nuclear pore complex; Nucleus envelope (UniProt). Locus 2q13 (HGNC).","whereFound":["Lung cancer: Open Targets association 0.59 with lung cancer (MONDO_0008903)","Hepatocellular carcinoma: IntOGen driver in 2 cohorts (HCC)","Renal cell carcinoma: IntOGen driver in 1 cohort (CCRCC)","Pheochromocytoma and paraganglioma: IntOGen driver in 1 cohort (PGNG)","Skin cancer: Open Targets association 0.55 with skin cancer (MONDO_0002898)","Breast cancer: Open Targets association 0.52 with breast cancer (MONDO_0007254)"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/ranbp2/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"clear-cell-rcc","kind":"cancer","name":"Clear cell renal cell carcinoma","route":"/cancers/clear-cell-rcc/"},{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"pheochromocytoma-paraganglioma","kind":"cancer","name":"Pheochromocytoma and paraganglioma (PPGL)","route":"/cancers/pheochromocytoma-paraganglioma/"},{"id":"rcc","kind":"cancer","name":"Renal cell carcinoma","route":"/cancers/rcc/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}