{"entity":{"id":"rap1a","kind":"target","name":"RAP1A","aka":["RAP1A, member of RAS oncogene family","Ras-related protein Rap-1A","KREV-1","SMGP21"],"tldr":"RAP1A (Ras-related protein Rap-1A) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localisation to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth.\n\nOpen Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.96, affected pathway 0.97, genetic association 0.00).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:9855","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9855"},{"label":"UniProt P62834","url":"https://www.uniprot.org/uniprotkb/P62834/entry"},{"label":"NCBI Gene 5906","url":"https://www.ncbi.nlm.nih.gov/gene/5906"},{"label":"Ensembl ENSG00000116473","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000116473"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"RAP1A","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:9855","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9855","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P62834","url":"https://www.uniprot.org/uniprotkb/P62834/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000116473","url":"https://platform.opentargets.org/target/ENSG00000116473/associations","note":"association with cancer (MONDO_0004992) 0.62;  (GraphQL API, CC0)"}],"hgnc":"HGNC:9855","ensembl":"ENSG00000116473","uniprot":"P62834","entrez":"5906","biology":"Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localisation to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. Facilitates the progressive accumulation of CDH1 at mature desmosome junctions via cAMP-dependent signalling and its interaction with PKP3. Location: Cell membrane; Cytoplasm; Cytoplasm, perinuclear region; Cell junction (UniProt). Locus 1p13.2 (HGNC).","whereFound":[],"targetClass":"enzyme","prevalence":[]},"route":"/targets/rap1a/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}