{"entity":{"id":"rasa1","kind":"target","name":"RASA1","aka":["RAS p21 protein activator 1","Ras GTPase-activating protein 1","CM-AVM","p120GAP","p120RASGAP","p120"],"tldr":"RASA1 (Ras GTPase-activating protein 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a drug target, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Head and neck squamous cell carcinoma, Colorectal cancer, Lung cancer and 4 more.","summary":"GTPase-activating protein (GAP) that stimulates the intrinsic GTPase activity of Ras proteins, such as NRAS, facilitating their transition from the active GTP-bound state to the inactive GDP-bound state, thereby terminating Ras signalling.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Trametinib. Open Targets scores its association with cancer at 0.77 (direct and indirect evidence; datatypes literature 0.94, animal model 0.42, genetic association 0.28, somatic mutation 0.91). IntOGen calls it a driver in 2 cohorts (0 activating, 2 loss-of-function), covering Head and Neck Squamous Cell Carcinoma, Lung Squamous Cell Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:9871","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9871"},{"label":"UniProt P20936","url":"https://www.uniprot.org/uniprotkb/P20936/entry"},{"label":"NCBI Gene 5921","url":"https://www.ncbi.nlm.nih.gov/gene/5921"},{"label":"Ensembl ENSG00000145715","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000145715"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets","intogen"],"cancers":["head-and-neck","colorectal","lung-cancer","skin-cancer","gastric","nsclc","basal-cell-carcinoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"RASA1","role":["drug-target","tumour-suppressor","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:9871","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9871","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P20936","url":"https://www.uniprot.org/uniprotkb/P20936/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene RASA1","url":"https://civicdb.org/features/4791","note":"1 evidence items, 0 assertions, 1 variants; diseases: Lung Non-small Cell Carcinoma (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000145715","url":"https://platform.opentargets.org/target/ENSG00000145715/associations","note":"association with cancer (MONDO_0004992) 0.77; per-cancer scores at or above 0.5: colorectal cancer 0.53, gastric cancer 0.51, skin cancer 0.52, basal cell carcinoma 0.52, lung cancer 0.53 (GraphQL API, CC0)"},{"label":"IntOGen RASA1","url":"https://www.intogen.org/search?gene=RASA1","note":"driver in 2 cohorts (Act 0, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:9871","ensembl":"ENSG00000145715","uniprot":"P20936","entrez":"5921","biology":"GTPase-activating protein (GAP) that stimulates the intrinsic GTPase activity of Ras proteins, such as NRAS, facilitating their transition from the active GTP-bound state to the inactive GDP-bound state, thereby terminating Ras signalling. Location: Cytoplasm (UniProt). Locus 5q14.3 (HGNC).","whereFound":["Head and neck squamous cell carcinoma: IntOGen driver in 1 cohort (HNSC)","Colorectal cancer: Open Targets association 0.53 with colorectal cancer (MONDO_0005575)","Lung cancer: Open Targets association 0.53 with lung cancer (MONDO_0008903)","Skin cancer: Open Targets association 0.52 with skin cancer (MONDO_0002898)","Gastric & gastro-oesophageal junction cancer: Open Targets association 0.51 with gastric cancer (MONDO_0001056)","Non-small-cell lung cancer: CIViC evidence names this disease; IntOGen driver in 1 cohort (LUSC)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/rasa1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"basal-cell-carcinoma","kind":"cancer","name":"Basal cell carcinoma","route":"/cancers/basal-cell-carcinoma/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"},{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}