{"entity":{"id":"rassf6","kind":"target","name":"RASSF6","aka":["Ras association domain family member 6","Ras association domain-containing protein 6"],"tldr":"RASSF6 (Ras association domain-containing protein 6) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.","summary":"Involved in the induction of apoptosis, through both caspase-dependent and caspase-independent pathways. May act as a Ras effector protein. May suppress the serum-induced basal levels of NF-kappa-B.\n\nOpen Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.93, genetic association 0.70).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:20796","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:20796"},{"label":"UniProt Q6ZTQ3","url":"https://www.uniprot.org/uniprotkb/Q6ZTQ3/entry"},{"label":"NCBI Gene 166824","url":"https://www.ncbi.nlm.nih.gov/gene/166824"},{"label":"Ensembl ENSG00000169435","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000169435"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["prostate"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"RASSF6","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:20796","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:20796","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q6ZTQ3","url":"https://www.uniprot.org/uniprotkb/Q6ZTQ3/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000169435","url":"https://platform.opentargets.org/target/ENSG00000169435/associations","note":"association with cancer (MONDO_0004992) 0.56; per-cancer scores at or above 0.5: prostate cancer 0.53 (GraphQL API, CC0)"}],"hgnc":"HGNC:20796","ensembl":"ENSG00000169435","uniprot":"Q6ZTQ3","entrez":"166824","biology":"Involved in the induction of apoptosis, through both caspase-dependent and caspase-independent pathways. May act as a Ras effector protein. May suppress the serum-induced basal levels of NF-kappa-B. Locus 4q13.3 (HGNC).","whereFound":["Prostate cancer: Open Targets association 0.53 with prostate cancer (MONDO_0008315)"],"targetClass":"other","prevalence":[]},"route":"/targets/rassf6/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}]}}