{"entity":{"id":"rbbp7","kind":"target","name":"RBBP7","aka":["RB binding protein 7, chromatin remodeling factor","Histone-binding protein RBBP7","RbAp46"],"tldr":"RBBP7 (Histone-binding protein RBBP7) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.\n\nOpen Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.92, affected pathway 0.76, genetic association 0.24).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:9890","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9890"},{"label":"UniProt Q16576","url":"https://www.uniprot.org/uniprotkb/Q16576/entry"},{"label":"NCBI Gene 5931","url":"https://www.ncbi.nlm.nih.gov/gene/5931"},{"label":"Ensembl ENSG00000102054","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000102054"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"RBBP7","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:9890","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9890","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q16576","url":"https://www.uniprot.org/uniprotkb/Q16576/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000102054","url":"https://platform.opentargets.org/target/ENSG00000102054/associations","note":"association with cancer (MONDO_0004992) 0.52;  (GraphQL API, CC0)"}],"hgnc":"HGNC:9890","ensembl":"ENSG00000102054","uniprot":"Q16576","entrez":"5931","biology":"Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. Location: Nucleus (UniProt). Locus Xp22.2 (HGNC).","whereFound":[],"targetClass":"transcription","prevalence":[]},"route":"/targets/rbbp7/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}