{"entity":{"id":"rbfox1","kind":"target","name":"RBFOX1","aka":["RNA binding fox-1 homolog 1","RNA binding protein fox-1 homolog 1","A2BP1","FOX-1","HRNBP1"],"tldr":"RBFOX1 (RNA binding protein fox-1 homolog 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer.","summary":"RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis.\n\nOpen Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.83, animal model 0.32, genetic association 0.66, somatic mutation 0.25). IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Prostate Adenocarcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:18222","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18222"},{"label":"UniProt Q9NWB1","url":"https://www.uniprot.org/uniprotkb/Q9NWB1/entry"},{"label":"NCBI Gene 54715","url":"https://www.ncbi.nlm.nih.gov/gene/54715"},{"label":"Ensembl ENSG00000078328","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000078328"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["prostate"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"RBFOX1","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:18222","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18222","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9NWB1","url":"https://www.uniprot.org/uniprotkb/Q9NWB1/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000078328","url":"https://platform.opentargets.org/target/ENSG00000078328/associations","note":"association with cancer (MONDO_0004992) 0.53;  (GraphQL API, CC0)"},{"label":"IntOGen RBFOX1","url":"https://www.intogen.org/search?gene=RBFOX1","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:18222","ensembl":"ENSG00000078328","uniprot":"Q9NWB1","entrez":"54715","biology":"RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis. Location: Nucleus; Cytoplasm (UniProt). Locus 16p13.3 (HGNC).","whereFound":["Prostate cancer: IntOGen driver in 1 cohort (PRAD)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/rbfox1/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}]}}