{"entity":{"id":"rbm10","kind":"target","name":"RBM10","aka":["RNA binding motif protein 10","Ribosome biogenesis inhibitor MINAS-60","DXS8237E","KIAA0122","GPATC9","ZRANB5","GPATCH9","S1-1"],"tldr":"RBM10 (Ribosome biogenesis inhibitor MINAS-60) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Lung cancer, Pancreatic ductal adenocarcinoma, Colorectal cancer and 4 more.","summary":"Acts as a late-stage inhibitor of pre-60S ribosome assembly by preventing pre-60S ribosome export from nucleus.\n\nOpen Targets scores its association with cancer at 0.75 (direct and indirect evidence; datatypes literature 0.98, animal model 0.43, genetic association 0.00, somatic mutation 0.97). IntOGen calls it a driver in 16 cohorts (1 activating, 15 loss-of-function), covering Bladder Urothelial Carcinoma, Cholangiocarcinoma, Colorectal Adenocarcinoma, Lung Adenocarcinoma, Non-Small Cell Lung Cancer, Pancreatic Adenocarcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:9896","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9896"},{"label":"UniProt P0DW28","url":"https://www.uniprot.org/uniprotkb/P0DW28/entry"},{"label":"NCBI Gene 8241","url":"https://www.ncbi.nlm.nih.gov/gene/8241"},{"label":"Ensembl ENSG00000182872","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000182872"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["lung-cancer","pancreatic","colorectal","urothelial","biliary-tract-cancer","nsclc","cholangiocarcinoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 15 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"RBM10","role":["oncogene-driver","tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:9896","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9896","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P0DW28","url":"https://www.uniprot.org/uniprotkb/P0DW28/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000182872","url":"https://platform.opentargets.org/target/ENSG00000182872/associations","note":"association with cancer (MONDO_0004992) 0.75; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.69, colorectal cancer 0.60, urinary bladder cancer 0.59, lung cancer 0.69, biliary tract cancer 0.58 (GraphQL API, CC0)"},{"label":"IntOGen RBM10","url":"https://www.intogen.org/search?gene=RBM10","note":"driver in 16 cohorts (Act 1, LoF 15); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:9896","ensembl":"ENSG00000182872","uniprot":"P0DW28","entrez":"8241","biology":"Acts as a late-stage inhibitor of pre-60S ribosome assembly by preventing pre-60S ribosome export from nucleus. Location: Nucleus, nucleolus (UniProt). Locus Xp11.3 (HGNC).","whereFound":["Lung cancer: Open Targets association 0.69 with lung cancer (MONDO_0008903)","Pancreatic ductal adenocarcinoma: IntOGen driver in 4 cohorts (PAAD)","Colorectal cancer: Open Targets association 0.60 with colorectal cancer (MONDO_0005575); IntOGen driver in 2 cohorts (COADREAD)","Bladder & urothelial cancer: Open Targets association 0.59 with urinary bladder cancer (MONDO_0001187); IntOGen driver in 2 cohorts (BLCA)","Biliary tract cancer: Open Targets association 0.58 with biliary tract cancer (MONDO_0003060)","Non-small-cell lung cancer: Open Targets association 0.69 with non-small cell lung carcinoma (MONDO_0005233); IntOGen driver in 7 cohorts (LUAD, NSCLC)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/rbm10/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"biliary-tract-cancer","kind":"cancer","name":"Biliary tract cancer (all types)","route":"/cancers/biliary-tract-cancer/"},{"id":"cholangiocarcinoma","kind":"cancer","name":"Biliary tract cancer (cholangiocarcinoma)","route":"/cancers/cholangiocarcinoma/"},{"id":"urothelial","kind":"cancer","name":"Bladder & urothelial cancer","route":"/cancers/urothelial/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"}]}}