{"entity":{"id":"rbm39","kind":"target","name":"RBM39","aka":["RNA binding motif protein 39","RNA-binding protein 39","CC1.3","HCC1","CAPER","fSAP59","CAPERalpha","RNPC2"],"tldr":"RBM39 (RNA-binding protein 39) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Endometrial cancer.","summary":"RNA-binding protein that acts as a pre-mRNA splicing factor. Acts by promoting exon inclusion via regulation of exon cassette splicing. Also acts as a transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1, independently of the pre-mRNA splicing factor activity.\n\nIntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Endometrial Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:15923","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:15923"},{"label":"UniProt Q14498","url":"https://www.uniprot.org/uniprotkb/Q14498/entry"},{"label":"NCBI Gene 9584","url":"https://www.ncbi.nlm.nih.gov/gene/9584"},{"label":"Ensembl ENSG00000131051","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000131051"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["endometrial"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"RBM39","role":["oncogene-driver"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:15923","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:15923","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q14498","url":"https://www.uniprot.org/uniprotkb/Q14498/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen RBM39","url":"https://www.intogen.org/search?gene=RBM39","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:15923","ensembl":"ENSG00000131051","uniprot":"Q14498","entrez":"9584","biology":"RNA-binding protein that acts as a pre-mRNA splicing factor. Acts by promoting exon inclusion via regulation of exon cassette splicing. Also acts as a transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1, independently of the pre-mRNA splicing factor activity. Location: Nucleus speckle (UniProt). Locus 20q11.22 (HGNC).","whereFound":["Endometrial cancer: IntOGen driver in 1 cohort (UCEC)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/rbm39/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"endometrial","kind":"cancer","name":"Endometrial cancer","route":"/cancers/endometrial/"}]}}