{"entity":{"id":"rbpj","kind":"target","name":"RBPJ","aka":["recombination signal binding protein for immunoglobulin kappa J region","Recombining binding protein suppressor of hairless","IGKJRB","RBPJK","KBF2","RBP-J","CBF1","IGKJRB1","RBPSUH"],"tldr":"RBPJ (Recombining binding protein suppressor of hairless) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Transcriptional regulator that plays a central role in Notch signalling, a signalling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes.\n\nOpen Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.96, affected pathway 0.95, animal model 0.35, genetic association 0.00).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:5724","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5724"},{"label":"UniProt Q06330","url":"https://www.uniprot.org/uniprotkb/Q06330/entry"},{"label":"NCBI Gene 3516","url":"https://www.ncbi.nlm.nih.gov/gene/3516"},{"label":"Ensembl ENSG00000168214","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000168214"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":["notch"],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"RBPJ","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:5724","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5724","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q06330","url":"https://www.uniprot.org/uniprotkb/Q06330/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000168214","url":"https://platform.opentargets.org/target/ENSG00000168214/associations","note":"association with cancer (MONDO_0004992) 0.61;  (GraphQL API, CC0)"}],"hgnc":"HGNC:5724","ensembl":"ENSG00000168214","uniprot":"Q06330","entrez":"3516","biology":"Transcriptional regulator that plays a central role in Notch signalling, a signalling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA. Location: Nucleus; Cytoplasm (UniProt). Locus 4p15.2 (HGNC).","whereFound":[],"targetClass":"transcription","prevalence":[]},"route":"/targets/rbpj/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"pathway":[{"id":"notch","kind":"pathway","name":"Notch signalling","route":"/pathways/notch/"}]}}