{"entity":{"id":"rec-4539","kind":"drug","name":"REC-4539","aka":["EXS74539"],"tldr":"REC-4539 is an experimental small molecule LSD1 inhibitor from Recursion Pharmaceuticals, in phase 1 trials for small-cell lung cancer, acute myeloid leukaemia and solid tumours.","summary":"REC-4539 (EXS74539) is a small molecule LSD1 inhibitor from Recursion Pharmaceuticals. Described by the company as the first LSD1 inhibitor designed to be both reversible and CNS-penetrant. Its furthest stage is phase 1, for small-cell lung cancer, acute myeloid leukaemia and solid tumours. ClinicalTrials.gov registers it in one study linked below. Pipeline page: 'Status: Phase 1'. Registry NCT07517198 recruiting (sponsor Exscientia AI Ltd., a wholly owned subsidiary of Recursion). Whether it works in people has not been established unless a trial below reports it.","status":"phase-1","asOf":"2026-11-03","links":[{"label":"Recursion Pharmaceuticals: recursion.com","url":"https://www.recursion.com/pipeline"},{"label":"Recursion Pharmaceuticals: clinicaltrials.gov","url":"https://clinicaltrials.gov/api/v2/studies/NCT07517198"},{"label":"ClinicalTrials.gov: trials of REC-4539","url":"https://clinicaltrials.gov/search?intr=REC-4539"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["sclc","metastatic-cancer"],"sections":[],"technologies":[],"targets":["lsd1"],"drugs":[],"companies":["recursion"],"institutions":[],"pathways":[],"terms":[],"trials":["nct07517198"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo gap audit, class 5 (company pipeline pages and ClinicalTrials.gov v2)","editedOn":"2026-11-03"},"code":"REC-4539","modality":"Small molecule LSD1 inhibitor","mechanism":"Described by the company as the first LSD1 inhibitor designed to be both reversible and CNS-penetrant.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/rec-4539/","neighbours":{"cancer":[{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"},{"id":"sclc","kind":"cancer","name":"Small-cell lung cancer","route":"/cancers/sclc/"}],"target":[{"id":"lsd1","kind":"target","name":"LSD1 (KDM1A)","route":"/targets/lsd1/"}],"company":[{"id":"recursion","kind":"company","name":"Recursion Pharmaceuticals","route":"/companies/recursion/"}],"trial":[{"id":"nct07517198","kind":"trial","name":"Dose Determining Study of EXS74539 (REC-4539) in Participants With Select Solid Tumors","route":"/trials/nct07517198/"}]}}