{"entity":{"id":"rec-7735","kind":"drug","name":"REC-7735","aka":[],"tldr":"REC-7735 is an experimental small molecule, mutant-selective PI3K-alpha inhibitor from Recursion Pharmaceuticals, in phase 1 trials for HR-positive / HER2-negative breast cancer with PIK3CA H1047R and solid tumours.","summary":"REC-7735 is a small molecule, mutant-selective PI3K-alpha inhibitor from Recursion Pharmaceuticals. A PI3K-alpha H1047R mutant-selective inhibitor, designed to avoid the dose-limiting high blood sugar seen with inhibitors of normal (wild-type) PI3K-alpha. Its furthest stage is phase 1, for HR-positive / HER2-negative breast cancer with PIK3CA H1047R and solid tumours. ClinicalTrials.gov registers it in one study linked below. Pipeline page: 'Status: Phase 1'. Registry NCT07819136 (phase 1/2) recruiting. Whether it works in people has not been established unless a trial below reports it.","status":"phase-1","asOf":"2026-11-03","links":[{"label":"Recursion Pharmaceuticals: recursion.com","url":"https://www.recursion.com/pipeline"},{"label":"Recursion Pharmaceuticals: recursion.com","url":"https://www.recursion.com/pipeline"},{"label":"ClinicalTrials.gov: trials of REC-7735","url":"https://clinicaltrials.gov/search?intr=REC-7735"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["metastatic-cancer"],"sections":[],"technologies":[],"targets":["pik3ca"],"drugs":[],"companies":["recursion"],"institutions":[],"pathways":[],"terms":[],"trials":["nct07819136"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo gap audit, class 5 (company pipeline pages and ClinicalTrials.gov v2)","editedOn":"2026-11-03"},"code":"REC-7735","modality":"Small molecule, mutant-selective PI3K-alpha inhibitor","mechanism":"A PI3K-alpha H1047R mutant-selective inhibitor, designed to avoid the dose-limiting high blood sugar seen with inhibitors of normal (wild-type) PI3K-alpha.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/rec-7735/","neighbours":{"cancer":[{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"}],"target":[{"id":"pik3ca","kind":"target","name":"PIK3CA / PI3K-alpha","route":"/targets/pik3ca/"}],"company":[{"id":"recursion","kind":"company","name":"Recursion Pharmaceuticals","route":"/companies/recursion/"}],"trial":[{"id":"nct07819136","kind":"trial","name":"REC-7735 in Participants With Solid Tumors","route":"/trials/nct07819136/"}]}}