{"entity":{"id":"reflection-galleri","kind":"trial","name":"REFLECTION (Galleri real-world learning programme)","aka":["REFLECTION","GRAIL-MA-001"],"tldr":"A registry that follows about 14,600 people who paid for or were offered Galleri in ordinary US clinics, to see how the test performs outside a trial.","summary":"REFLECTION (NCT05205967) is an observational study sponsored by GRAIL, Inc. Its primary outcome is signal detection and cancer detection within and across sites among people who opted to have Galleri.\n\nThe registry record, read on 29 October 2026, gives its status as active, not recruiting, with 14,633 participants enrolled, a start on 23 August 2021 and primary completion on 30 September 2025.","status":"active","asOf":"2026-10-29","links":[{"label":"ClinicalTrials.gov NCT05205967","url":"https://clinicaltrials.gov/study/NCT05205967"}],"tags":[],"related":[],"cancers":[],"sections":["early-detection"],"technologies":["mced","liquid-biopsy"],"targets":[],"drugs":["galleri"],"companies":["grail"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT05205967","phase":"observational","setting":"People in the United States who chose to have the Galleri test in routine clinical care, followed for signal and cancer detection","sponsor":"GRAIL, Inc.","started":"2021-08-23","startedType":"actual","enrolled":14633,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/reflection-galleri/","neighbours":{"section":[{"id":"early-detection","kind":"section","name":"Early Detection & Screening","route":"/fronts/early-detection/"}],"technology":[{"id":"liquid-biopsy","kind":"technology","name":"Liquid biopsy (ctDNA)","route":"/technologies/liquid-biopsy/"},{"id":"mced","kind":"technology","name":"Multi-cancer early detection (MCED)","route":"/technologies/mced/"}],"drug":[{"id":"galleri","kind":"drug","name":"Galleri","route":"/drugs/galleri/"}],"company":[{"id":"grail","kind":"company","name":"GRAIL","route":"/companies/grail/"}]}}