{"entity":{"id":"rel","kind":"target","name":"REL","aka":["REL proto-oncogene, NF-kB subunit","Proto-oncogene c-Rel","I-Rel","c-Rel","HIVEN86A"],"tldr":"REL (Proto-oncogene c-Rel) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer and Diffuse large B-cell lymphoma.","summary":"Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 2 variants. Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.80, animal model 0.51, genetic association 0.00, somatic mutation 0.96).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:9954","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9954"},{"label":"UniProt Q04864","url":"https://www.uniprot.org/uniprotkb/Q04864/entry"},{"label":"NCBI Gene 5966","url":"https://www.ncbi.nlm.nih.gov/gene/5966"},{"label":"Ensembl ENSG00000162924","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000162924"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets"],"cancers":["ovarian","dlbcl"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"REL","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:9954","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9954","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q04864","url":"https://www.uniprot.org/uniprotkb/Q04864/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene REL","url":"https://civicdb.org/features/57","note":"1 evidence items, 0 assertions, 2 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000162924","url":"https://platform.opentargets.org/target/ENSG00000162924/associations","note":"association with cancer (MONDO_0004992) 0.61; per-cancer scores at or above 0.5: ovarian cancer 0.50 (GraphQL API, CC0)"}],"hgnc":"HGNC:9954","ensembl":"ENSG00000162924","uniprot":"Q04864","entrez":"5966","biology":"Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalisation as well as by interactions with other cofactors or corepressors. Location: Nucleus (UniProt). Locus 2p16.1 (HGNC).","whereFound":["Ovarian cancer: Open Targets association 0.50 with ovarian cancer (MONDO_0008170)","Diffuse large B-cell lymphoma: CIViC evidence names this disease"],"targetClass":"transcription","prevalence":[]},"route":"/targets/rel/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"dlbcl","kind":"cancer","name":"Diffuse large B-cell lymphoma","route":"/cancers/dlbcl/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"}]}}