{"entity":{"id":"remi-nout","kind":"person","name":"Remi A. Nout","aka":[],"tldr":"Dutch radiation oncologist who was lead author of PORTEC-2, the trial that showed vaginal brachytherapy is as good as pelvic radiotherapy for high-intermediate-risk endometrial cancer, with fewer side effects.","summary":"Remi Nout is a radiation oncologist who trained in the Leiden PORTEC group and now leads radiation oncology at Erasmus MC in Rotterdam. He was first author of the 2010 Lancet report of PORTEC-2, in which vaginal brachytherapy gave vaginal recurrence control equivalent to external-beam pelvic radiotherapy in high-intermediate-risk endometrial cancer with less bowel toxicity and better quality of life, making brachytherapy the standard adjuvant treatment for this group. He also leads international trials in cervical cancer radiotherapy.","asOf":"2026-09-18","links":[],"tags":["endometrial","radiotherapy","trialist"],"related":[],"cancers":["endometrial-nsmp","endometrial","cervical"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":["erasmus-mc"],"pathways":[],"terms":[],"trials":["portec-2"],"people":[],"bottlenecks":[],"keyPapers":["paper-portec-2-lancet-2010"],"journals":[],"dependsOn":[],"notes":[],"role":"Professor of Radiation Oncology, Erasmus MC, Rotterdam","institutionId":"erasmus-mc","specialisms":["Endometrial cancer radiotherapy","Vaginal brachytherapy","Cervical cancer radiotherapy"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Nout%5BAuthor%5D"}],"papers":[]},"route":"/people/remi-nout/","neighbours":{"cancer":[{"id":"cervical","kind":"cancer","name":"Cervical cancer","route":"/cancers/cervical/"},{"id":"endometrial","kind":"cancer","name":"Endometrial cancer","route":"/cancers/endometrial/"},{"id":"endometrial-nsmp","kind":"cancer","name":"Endometrial cancer with no specific molecular profile","route":"/cancers/endometrial-nsmp/"}],"institution":[{"id":"erasmus-mc","kind":"institution","name":"Erasmus MC Cancer Institute","route":"/institutions/erasmus-mc/"}],"trial":[{"id":"portec-2","kind":"trial","name":"PORTEC-2","route":"/trials/portec-2/"}],"paper":[{"id":"paper-portec-2-lancet-2010","kind":"paper","name":"PORTEC-2: vaginal brachytherapy versus pelvic external beam radiotherapy for high-intermediate-risk endometrial cancer","route":"/key-papers/paper-portec-2-lancet-2010/"}]}}