{"entity":{"id":"rfx7","kind":"target","name":"RFX7","aka":["regulatory factor X7","DNA-binding protein RFX7","FLJ12994","RFXDC2"],"tldr":"RFX7 (DNA-binding protein RFX7) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer and Burkitt lymphoma.","summary":"Transcription factor. Acts as a transcriptional activator by binding to promoter regions of target genes, such as PDCD4, PIK3IP1, MXD4, PNRC1, and RFX5. Plays a role in natural killer (NK) cell maintenance and immunity.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.66, animal model 0.32, genetic association 0.68).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:25777","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25777"},{"label":"UniProt Q2KHR2","url":"https://www.uniprot.org/uniprotkb/Q2KHR2/entry"},{"label":"NCBI Gene 64864","url":"https://www.ncbi.nlm.nih.gov/gene/64864"},{"label":"Ensembl ENSG00000181827","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000181827"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets"],"cancers":["prostate","burkitt-lymphoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"RFX7","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:25777","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25777","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q2KHR2","url":"https://www.uniprot.org/uniprotkb/Q2KHR2/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene RFX7","url":"https://civicdb.org/features/14525","note":"1 evidence items, 0 assertions, 1 variants; diseases: Burkitt Lymphoma (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000181827","url":"https://platform.opentargets.org/target/ENSG00000181827/associations","note":"association with cancer (MONDO_0004992) 0.54; per-cancer scores at or above 0.5: prostate cancer 0.51 (GraphQL API, CC0)"}],"hgnc":"HGNC:25777","ensembl":"ENSG00000181827","uniprot":"Q2KHR2","entrez":"64864","biology":"Transcription factor. Acts as a transcriptional activator by binding to promoter regions of target genes, such as PDCD4, PIK3IP1, MXD4, PNRC1, and RFX5. Plays a role in natural killer (NK) cell maintenance and immunity. May play a role in the process of ciliogenesis in the neural tube and neural tube closure. Location: Nucleus (UniProt). Locus 15q21.3 (HGNC).","whereFound":["Prostate cancer: Open Targets association 0.51 with prostate cancer (MONDO_0008315)","Burkitt lymphoma: CIViC evidence names this disease"],"targetClass":"transcription","prevalence":[]},"route":"/targets/rfx7/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"burkitt-lymphoma","kind":"cancer","name":"Burkitt lymphoma","route":"/cancers/burkitt-lymphoma/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}]}}