{"entity":{"id":"rgpd3","kind":"target","name":"RGPD3","aka":["RANBP2 like and GRIP domain containing 3","RanBP2-like and GRIP domain-containing protein 3","RGP3"],"tldr":"RGPD3 (RanBP2-like and GRIP domain-containing protein 3) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma, Non-small-cell lung cancer and Melanoma.","summary":"UniProt has no function text for A6NKT7; HGNC names it \"RANBP2 like and GRIP domain containing 3\".\n\nIntOGen calls it a driver in 3 cohorts (1 activating, 2 loss-of-function), covering Hepatocellular Carcinoma, Lung Squamous Cell Carcinoma, Melanoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:32416","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:32416"},{"label":"UniProt A6NKT7","url":"https://www.uniprot.org/uniprotkb/A6NKT7/entry"},{"label":"NCBI Gene 653489","url":"https://www.ncbi.nlm.nih.gov/gene/653489"},{"label":"Ensembl ENSG00000153165","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000153165"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["hcc","nsclc","melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"RGPD3","role":["oncogene-driver","tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:32416","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:32416","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt A6NKT7","url":"https://www.uniprot.org/uniprotkb/A6NKT7/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen RGPD3","url":"https://www.intogen.org/search?gene=RGPD3","note":"driver in 3 cohorts (Act 1, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:32416","ensembl":"ENSG00000153165","uniprot":"A6NKT7","entrez":"653489","biology":"UniProt has no function text for A6NKT7; HGNC names it \"RANBP2 like and GRIP domain containing 3\". Locus 2q12.2 (HGNC).","whereFound":["Hepatocellular carcinoma: IntOGen driver in 1 cohort (HCC)","Non-small-cell lung cancer: IntOGen driver in 1 cohort (LUSC)","Melanoma: IntOGen driver in 1 cohort (MEL)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/rgpd3/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}]}}