{"entity":{"id":"rgs17","kind":"target","name":"RGS17","aka":["regulator of G protein signaling 17","Regulator of G protein signaling 17","RGSZ2","RGS-17"],"tldr":"RGS17 (Regulator of G protein signalling 17) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.","summary":"Regulates G protein-coupled receptor signalling cascades, including signalling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Binds selectively to GNAZ and GNAI2 subunits, accelerates their GTPase activity and regulates their signalling activities.\n\nOpen Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.92, genetic association 0.66).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:14088","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14088"},{"label":"UniProt Q9UGC6","url":"https://www.uniprot.org/uniprotkb/Q9UGC6/entry"},{"label":"NCBI Gene 26575","url":"https://www.ncbi.nlm.nih.gov/gene/26575"},{"label":"Ensembl ENSG00000091844","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000091844"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["prostate"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"RGS17","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:14088","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14088","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9UGC6","url":"https://www.uniprot.org/uniprotkb/Q9UGC6/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000091844","url":"https://platform.opentargets.org/target/ENSG00000091844/associations","note":"association with cancer (MONDO_0004992) 0.53; per-cancer scores at or above 0.5: prostate cancer 0.52 (GraphQL API, CC0)"}],"hgnc":"HGNC:14088","ensembl":"ENSG00000091844","uniprot":"Q9UGC6","entrez":"26575","biology":"Regulates G protein-coupled receptor signalling cascades, including signalling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Binds selectively to GNAZ and GNAI2 subunits, accelerates their GTPase activity and regulates their signalling activities. Negatively regulates mu-opioid receptor-mediated activation of the G proteins. Location: Membrane; Synapse, synaptosome; Nucleus; Cytoplasm (UniProt). Locus 6q25.2 (HGNC).","whereFound":["Prostate cancer: Open Targets association 0.52 with prostate cancer (MONDO_0008315)"],"targetClass":"other","prevalence":[]},"route":"/targets/rgs17/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}]}}