{"entity":{"id":"rgs7","kind":"target","name":"RGS7","aka":["regulator of G protein signaling 7","Regulator of G protein signaling 7"],"tldr":"RGS7 (Regulator of G protein signalling 7) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Non-small-cell lung cancer and Melanoma.","summary":"GTPase activator component of the RGS7-GNB5 complex that regulates G protein-coupled receptor signalling cascades. The RGS7-GNB5 complex acts as an inhibitor signal transduction by promoting the GTPase activity of G protein alpha subunits, such as GNAO1, thereby driving them into their inactive GDP-bound form. May play a role in synaptic vesicle exocytosis.\n\nIntOGen calls it a driver in 6 cohorts (4 activating, 2 loss-of-function), covering Invasive Breast Carcinoma, Lung Adenocarcinoma, Lung Squamous Cell Carcinoma, Melanoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:10003","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10003"},{"label":"UniProt P49802","url":"https://www.uniprot.org/uniprotkb/P49802/entry"},{"label":"NCBI Gene 6000","url":"https://www.ncbi.nlm.nih.gov/gene/6000"},{"label":"Ensembl ENSG00000182901","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000182901"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["breast-cancer","nsclc","melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 4 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"RGS7","role":["oncogene-driver","tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:10003","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10003","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P49802","url":"https://www.uniprot.org/uniprotkb/P49802/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen RGS7","url":"https://www.intogen.org/search?gene=RGS7","note":"driver in 6 cohorts (Act 4, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:10003","ensembl":"ENSG00000182901","uniprot":"P49802","entrez":"6000","biology":"GTPase activator component of the RGS7-GNB5 complex that regulates G protein-coupled receptor signalling cascades. The RGS7-GNB5 complex acts as an inhibitor signal transduction by promoting the GTPase activity of G protein alpha subunits, such as GNAO1, thereby driving them into their inactive GDP-bound form. May play a role in synaptic vesicle exocytosis. Glycine-dependent regulation of the RGS7-GNB5 complex by GPR158 affects mood and cognition via its ability to regulate neuronal excitability in L2/L3 pyramidal neurons of the prefrontal cortex. Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signalling. Location: Cytoplasm, cytosol; Cytoplasm; Cell membrane; Membrane (UniProt). Locus 1q43 (HGNC).","whereFound":["Breast cancer: IntOGen driver in 1 cohort (BRCA)","Non-small-cell lung cancer: IntOGen driver in 3 cohorts (LUAD, LUSC)","Melanoma: IntOGen driver in 2 cohorts (MEL)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/rgs7/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}]}}