{"entity":{"id":"rhobtb2","kind":"target","name":"RHOBTB2","aka":["Rho related BTB domain containing 2","Rho-related BTB domain-containing protein 2","KIAA0717","DBC2"],"tldr":"RHOBTB2 (Rho-related BTB domain-containing protein 2) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Regulator of cell proliferation and apoptosis. It likely functions as a substrate-adapter that recruits key substrates, e.g. MSI2, to CUL3-based ubiquitin ligase complexes for degradation.\n\nOpen Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.93, genetic association 0.67, somatic mutation 0.23).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:18756","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18756"},{"label":"UniProt Q9BYZ6","url":"https://www.uniprot.org/uniprotkb/Q9BYZ6/entry"},{"label":"NCBI Gene 23221","url":"https://www.ncbi.nlm.nih.gov/gene/23221"},{"label":"Ensembl ENSG00000008853","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000008853"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"RHOBTB2","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:18756","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18756","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9BYZ6","url":"https://www.uniprot.org/uniprotkb/Q9BYZ6/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000008853","url":"https://platform.opentargets.org/target/ENSG00000008853/associations","note":"association with cancer (MONDO_0004992) 0.56;  (GraphQL API, CC0)"}],"hgnc":"HGNC:18756","ensembl":"ENSG00000008853","uniprot":"Q9BYZ6","entrez":"23221","biology":"Regulator of cell proliferation and apoptosis. It likely functions as a substrate-adapter that recruits key substrates, e.g. MSI2, to CUL3-based ubiquitin ligase complexes for degradation. Required for MSI2 ubiquitination and degradation. Locus 8p21.3 (HGNC).","whereFound":[],"targetClass":"enzyme","prevalence":[]},"route":"/targets/rhobtb2/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}