{"entity":{"id":"rhoh","kind":"target","name":"RHOH","aka":["ras homolog family member H","Rho-related GTP-binding protein RhoH"],"tldr":"RHOH (Rho-related GTP-binding protein RhoH) is an enzyme. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Breast cancer.","summary":"Negative regulator of haematopoietic progenitor cell proliferation, survival and migration. Critical regulator of thymocyte development and T-cell antigen receptor (TCR) signalling by mediating recruitment and activation of ZAP70. Required for phosphorylation of CD3Z, membrane translocation of ZAP70 and subsequent activation of the ZAP70-mediated pathways.\n\nOpen Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.87, genetic association 0.00, somatic mutation 0.95).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:686","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:686"},{"label":"UniProt Q15669","url":"https://www.uniprot.org/uniprotkb/Q15669/entry"},{"label":"NCBI Gene 399","url":"https://www.ncbi.nlm.nih.gov/gene/399"},{"label":"Ensembl ENSG00000168421","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000168421"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["breast-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"RHOH","role":["fusion-partner"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:686","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:686","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q15669","url":"https://www.uniprot.org/uniprotkb/Q15669/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000168421","url":"https://platform.opentargets.org/target/ENSG00000168421/associations","note":"association with cancer (MONDO_0004992) 0.60; per-cancer scores at or above 0.5: breast cancer 0.52 (GraphQL API, CC0)"}],"hgnc":"HGNC:686","ensembl":"ENSG00000168421","uniprot":"Q15669","entrez":"399","biology":"Negative regulator of haematopoietic progenitor cell proliferation, survival and migration. Critical regulator of thymocyte development and T-cell antigen receptor (TCR) signalling by mediating recruitment and activation of ZAP70. Required for phosphorylation of CD3Z, membrane translocation of ZAP70 and subsequent activation of the ZAP70-mediated pathways. Essential for efficient beta-selection and positive selection by promoting the ZAP70-dependent phosphorylation of the LAT signalosome during pre-TCR and TCR signalling. Crucial for thymocyte maturation during DN3 to DN4 transition and during positive selection. Plays critical roles in mast cell function by facilitating phosphorylation of SYK in Fc epsilon RI-mediated signal transduction. Location: Cytoplasm; Cell membrane (UniProt). Locus 4p14 (HGNC).","whereFound":["Breast cancer: Open Targets association 0.52 with breast cancer (MONDO_0007254)"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/rhoh/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"}]}}