{"entity":{"id":"rhpn2","kind":"target","name":"RHPN2","aka":["rhophilin Rho GTPase binding protein 2","Rhophilin-2"],"tldr":"RHPN2 (Rhophilin-2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer and Non-small-cell lung cancer.","summary":"Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fibre formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity.\n\nOpen Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.95, genetic association 0.64, somatic mutation 0.78). IntOGen calls it a driver in 3 cohorts (1 activating, 2 loss-of-function), covering Invasive Breast Carcinoma, Lung Adenocarcinoma, Lung Squamous Cell Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:19974","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:19974"},{"label":"UniProt Q8IUC4","url":"https://www.uniprot.org/uniprotkb/Q8IUC4/entry"},{"label":"NCBI Gene 85415","url":"https://www.ncbi.nlm.nih.gov/gene/85415"},{"label":"Ensembl ENSG00000131941","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000131941"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["breast-cancer","nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"RHPN2","role":["oncogene-driver","tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:19974","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:19974","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q8IUC4","url":"https://www.uniprot.org/uniprotkb/Q8IUC4/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000131941","url":"https://platform.opentargets.org/target/ENSG00000131941/associations","note":"association with cancer (MONDO_0004992) 0.62;  (GraphQL API, CC0)"},{"label":"IntOGen RHPN2","url":"https://www.intogen.org/search?gene=RHPN2","note":"driver in 3 cohorts (Act 1, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:19974","ensembl":"ENSG00000131941","uniprot":"Q8IUC4","entrez":"85415","biology":"Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fibre formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity. Location: Cytoplasm, perinuclear region (UniProt). Locus 19q13.11 (HGNC).","whereFound":["Breast cancer: IntOGen driver in 1 cohort (BRCA)","Non-small-cell lung cancer: IntOGen driver in 2 cohorts (LUAD, LUSC)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/rhpn2/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}]}}