{"entity":{"id":"rit1","kind":"target","name":"RIT1","aka":["Ras like without CAAX 1","GTP-binding protein Rit1","ROC1","MGC125864","MGC125865"],"tldr":"RIT1 (GTP-binding protein Rit1) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Endometrial cancer and Non-small-cell lung cancer.","summary":"Plays a crucial role in coupling nerve growth factor (NGF) stimulation to the activation of both EPHB2 and MAPK14 signalling pathways and in NGF-dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signalling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation. Recognised by LZTR1, which mediates its ubiquitination by a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex.\n\nCIViC holds 14 clinical evidence items and 0 assertions across 8 variants, naming Selumetinib and Pictilisib.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:10023","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10023"},{"label":"UniProt Q92963","url":"https://www.uniprot.org/uniprotkb/Q92963/entry"},{"label":"NCBI Gene 6016","url":"https://www.ncbi.nlm.nih.gov/gene/6016"},{"label":"Ensembl ENSG00000143622","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000143622"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["endometrial","nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 14 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"RIT1","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:10023","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10023","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q92963","url":"https://www.uniprot.org/uniprotkb/Q92963/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene RIT1","url":"https://civicdb.org/features/4875","note":"14 evidence items, 0 assertions, 8 variants; diseases: Lung Adenocarcinoma, Endometrial Cancer (GraphQL API, CC0)"}],"hgnc":"HGNC:10023","ensembl":"ENSG00000143622","uniprot":"Q92963","entrez":"6016","biology":"Plays a crucial role in coupling nerve growth factor (NGF) stimulation to the activation of both EPHB2 and MAPK14 signalling pathways and in NGF-dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signalling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation. Recognised by LZTR1, which mediates its ubiquitination by a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. Location: Cell membrane (UniProt). Locus 1q22 (HGNC).","whereFound":["Endometrial cancer: CIViC evidence names this disease","Non-small-cell lung cancer: CIViC evidence names this disease"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/rit1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"endometrial","kind":"cancer","name":"Endometrial cancer","route":"/cancers/endometrial/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}]}}