{"entity":{"id":"rmi2","kind":"target","name":"RMI2","aka":["RecQ mediated genome instability 2","RecQ-mediated genome instability protein 2","MGC24665","BLAP18","C16orf75"],"tldr":"RMI2 (RecQ-mediated genome instability protein 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Non-Hodgkin lymphoma, Breast cancer, Lung cancer and 1 more.","summary":"Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is required to regulate sister chromatid segregation and to limit DNA crossover. Essential for the stability, localisation, and function of BLM, TOP3A, and complexes containing BLM.\n\nOpen Targets scores its association with cancer at 0.76 (direct and indirect evidence; datatypes literature 0.89, affected pathway 0.87, genetic association 0.41, somatic mutation 0.97).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:28349","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:28349"},{"label":"UniProt Q96E14","url":"https://www.uniprot.org/uniprotkb/Q96E14/entry"},{"label":"NCBI Gene 116028","url":"https://www.ncbi.nlm.nih.gov/gene/116028"},{"label":"Ensembl ENSG00000175643","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000175643"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["non-hodgkin-lymphoma","breast-cancer","lung-cancer","dlbcl"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"RMI2","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:28349","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:28349","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q96E14","url":"https://www.uniprot.org/uniprotkb/Q96E14/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000175643","url":"https://platform.opentargets.org/target/ENSG00000175643/associations","note":"association with cancer (MONDO_0004992) 0.76; per-cancer scores at or above 0.5: diffuse large B-cell lymphoma 0.57, non-Hodgkin lymphoma 0.61, breast cancer 0.54, lung cancer 0.50 (GraphQL API, CC0)"}],"hgnc":"HGNC:28349","ensembl":"ENSG00000175643","uniprot":"Q96E14","entrez":"116028","biology":"Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is required to regulate sister chromatid segregation and to limit DNA crossover. Essential for the stability, localisation, and function of BLM, TOP3A, and complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM. Location: Nucleus (UniProt). Locus 16p13.13 (HGNC).","whereFound":["Non-Hodgkin lymphoma: Open Targets association 0.61 with non-Hodgkin lymphoma (MONDO_0018908)","Breast cancer: Open Targets association 0.54 with breast cancer (MONDO_0007254)","Lung cancer: Open Targets association 0.50 with lung cancer (MONDO_0008903)","Diffuse large B-cell lymphoma: Open Targets association 0.57 with diffuse large B-cell lymphoma (MONDO_0018905)"],"targetClass":"other","prevalence":[]},"route":"/targets/rmi2/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"dlbcl","kind":"cancer","name":"Diffuse large B-cell lymphoma","route":"/cancers/dlbcl/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"}]}}