{"entity":{"id":"rnaset2","kind":"target","name":"RNASET2","aka":["ribonuclease T2","Ribonuclease T2","RNASE6PL","FLJ10907","bA514O12.3"],"tldr":"RNASET2 (Ribonuclease T2) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Basal cell carcinoma.","summary":"Ribonuclease that plays an essential role in innate immune response by recognising and degrading RNAs from microbial pathogens that are subsequently sensed by TLR8. Cleaves preferentially single-stranded RNA molecules between purine and uridine residues, which critically contributes to the supply of catabolic uridine and the generation of purine-2',3'-cyclophosphate-terminated oligoribonucleotides. In turn, RNase T2 degradation products promote the RNA-dependent activation of TLR8.\n\nOpen Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.95, genetic association 0.70).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:21686","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:21686"},{"label":"UniProt O00584","url":"https://www.uniprot.org/uniprotkb/O00584/entry"},{"label":"NCBI Gene 8635","url":"https://www.ncbi.nlm.nih.gov/gene/8635"},{"label":"Ensembl ENSG00000026297","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000026297"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["basal-cell-carcinoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"RNASET2","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:21686","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:21686","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O00584","url":"https://www.uniprot.org/uniprotkb/O00584/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000026297","url":"https://platform.opentargets.org/target/ENSG00000026297/associations","note":"association with cancer (MONDO_0004992) 0.56; per-cancer scores at or above 0.5: basal cell carcinoma 0.53 (GraphQL API, CC0)"}],"hgnc":"HGNC:21686","ensembl":"ENSG00000026297","uniprot":"O00584","entrez":"8635","biology":"Ribonuclease that plays an essential role in innate immune response by recognising and degrading RNAs from microbial pathogens that are subsequently sensed by TLR8. Cleaves preferentially single-stranded RNA molecules between purine and uridine residues, which critically contributes to the supply of catabolic uridine and the generation of purine-2',3'-cyclophosphate-terminated oligoribonucleotides. In turn, RNase T2 degradation products promote the RNA-dependent activation of TLR8. In plasmacytoid dendritic cells, it cooperates with PLD3 or PLD4 5'->3' exonucleases to process RNA fragments and release 2',3'-cyclic guanosine monophosphate (2',3'-cGMP), a potent stimulatory ligand for TLR7. Also plays a key role in degradation of mitochondrial RNA and processing of non-coding RNA imported from the cytosol into mitochondria. Participates as well in degradation of mitochondrion-associated cytosolic rRNAs. Location: Secreted; Lysosome lumen; Endoplasmic reticulum lumen; Mitochondrion intermembrane space (UniProt). Locus 6q27 (HGNC).","whereFound":["Basal cell carcinoma: Open Targets association 0.53 with basal cell carcinoma (MONDO_0020804)"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/rnaset2/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"basal-cell-carcinoma","kind":"cancer","name":"Basal cell carcinoma","route":"/cancers/basal-cell-carcinoma/"}]}}