{"entity":{"id":"rnf43","kind":"target","name":"RNF43","aka":["ring finger protein 43","E3 ubiquitin-protein ligase RNF43","FLJ20315","RNF124","DKFZp781H0392"],"tldr":"RNF43 (E3 ubiquitin-protein ligase RNF43) is an enzyme. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma, Colorectal cancer, Gastric & gastro-oesophageal junction cancer and 5 more.","summary":"E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signalling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signalling pathway. Along with RSPO2 and ZNRF3, constitutes a master switch that governs limb specification.\n\nOpen Targets scores its association with cancer at 0.82 (direct and indirect evidence; datatypes affected pathway 0.61, literature 0.98, genetic association 0.57, somatic mutation 0.97, animal model 0.68). IntOGen calls it a driver in 21 cohorts (4 activating, 17 loss-of-function), covering Cholangiocarcinoma, Colon Adenocarcinoma, Colorectal Adenocarcinoma, Oesophageal Adenocarcinoma, Lung Squamous Cell Carcinoma, Ovarian Epithelial Tumour and others.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:18505","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18505"},{"label":"UniProt Q68DV7","url":"https://www.uniprot.org/uniprotkb/Q68DV7/entry"},{"label":"NCBI Gene 54894","url":"https://www.ncbi.nlm.nih.gov/gene/54894"},{"label":"Ensembl ENSG00000108375","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000108375"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["pancreatic","colorectal","gastric","prostate","esophageal","ovarian","endometrial","lung-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":["wnt"],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 4 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 17 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"RNF43","role":["oncogene-driver","tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:18505","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18505","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q68DV7","url":"https://www.uniprot.org/uniprotkb/Q68DV7/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000108375","url":"https://platform.opentargets.org/target/ENSG00000108375/associations","note":"association with cancer (MONDO_0004992) 0.82; per-cancer scores at or above 0.5: colorectal cancer 0.65, gastric cancer 0.63, prostate cancer 0.55, ovarian cancer 0.51, skin cancer 0.52, lung cancer 0.56 (GraphQL API, CC0)"},{"label":"IntOGen RNF43","url":"https://www.intogen.org/search?gene=RNF43","note":"driver in 21 cohorts (Act 4, LoF 17); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:18505","ensembl":"ENSG00000108375","uniprot":"Q68DV7","entrez":"54894","biology":"E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signalling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signalling pathway. Along with RSPO2 and ZNRF3, constitutes a master switch that governs limb specification. Location: Cell membrane; Endoplasmic reticulum membrane; Nucleus envelope (UniProt). Locus 17q22 (HGNC).","whereFound":["Pancreatic ductal adenocarcinoma: IntOGen driver in 7 cohorts (PAAD, PANCREAS)","Colorectal cancer: Open Targets association 0.65 with colorectal cancer (MONDO_0005575); IntOGen driver in 3 cohorts (COAD, COADREAD)","Gastric & gastro-oesophageal junction cancer: Open Targets association 0.63 with gastric cancer (MONDO_0001056); IntOGen driver in 2 cohorts (STAD)","Prostate cancer: Open Targets association 0.55 with prostate cancer (MONDO_0008315); IntOGen driver in 3 cohorts (PRAD, PROSTATE)","Oesophageal cancer: IntOGen driver in 2 cohorts (ESCA)","Ovarian cancer: Open Targets association 0.51 with ovarian cancer (MONDO_0008170); IntOGen driver in 1 cohort (OVT)"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/rnf43/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"endometrial","kind":"cancer","name":"Endometrial cancer","route":"/cancers/endometrial/"},{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"esophageal","kind":"cancer","name":"Oesophageal cancer","route":"/cancers/esophageal/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}],"pathway":[{"id":"wnt","kind":"pathway","name":"Wnt / β-catenin","route":"/pathways/wnt/"}]}}