{"entity":{"id":"robo4","kind":"target","name":"ROBO4","aka":["roundabout guidance receptor 4","Roundabout homolog 4","FLJ20798","ECSM4"],"tldr":"ROBO4 (Roundabout homolog 4) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.","summary":"Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins. Involved in the maintenance of endothelial barrier organisation and function.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Angiogenesis Inhibitor.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:17985","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17985"},{"label":"UniProt Q8WZ75","url":"https://www.uniprot.org/uniprotkb/Q8WZ75/entry"},{"label":"NCBI Gene 54538","url":"https://www.ncbi.nlm.nih.gov/gene/54538"},{"label":"Ensembl ENSG00000154133","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000154133"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ROBO4","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:17985","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17985","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q8WZ75","url":"https://www.uniprot.org/uniprotkb/Q8WZ75/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene ROBO4","url":"https://civicdb.org/features/12367","note":"1 evidence items, 0 assertions, 1 variants; diseases: Cancer (GraphQL API, CC0)"}],"hgnc":"HGNC:17985","ensembl":"ENSG00000154133","uniprot":"Q8WZ75","entrez":"54538","biology":"Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins. Involved in the maintenance of endothelial barrier organisation and function. Locus 11q24.2 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/robo4/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}]}}