{"entity":{"id":"ron","kind":"target","name":"RON receptor (MST1R)","aka":[],"tldr":"RON is a receptor kinase from the same family as MET; multi-kinase drugs such as crizotinib and cabozantinib hit it as well as their main targets.","summary":"Macrophage-stimulating protein receptor (RON, gene MST1R) is the sister receptor of MET, activated by MSP and overexpressed or aberrantly spliced in several carcinomas, where it promotes invasion and macrophage-driven inflammation. It is not a primary approval target, but crizotinib, cabozantinib and other MET-family inhibitors inhibit it and ChEMBL lists it among their targets.","asOf":"2026-09-04","wikipedia":"https://en.wikipedia.org/wiki/MST1R","links":[{"label":"UniProt Q04912: MST1R","url":"https://www.uniprot.org/uniprotkb/Q04912/entry"},{"label":"HGNC:7381 MST1R","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7381"},{"label":"ChEMBL target CHEMBL2689","url":"https://www.ebi.ac.uk/chembl/explore/target/CHEMBL2689"}],"tags":[],"related":["met"],"cancers":["nsclc","colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":["crizotinib","cabozantinib"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"symbol":"MST1R","biology":"A receptor tyrosine kinase signalling through PI3K, MAPK and beta-catenin pathways; short isoforms act as constitutively active oncogenes.","whereFound":["Overexpressed in subsets of breast, colon, pancreatic and lung carcinomas","Macrophages"],"targetClass":"kinase","prevalence":[]},"route":"/targets/ron/","neighbours":{"target":[{"id":"met","kind":"target","name":"MET","route":"/targets/met/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}],"drug":[{"id":"cabozantinib","kind":"drug","name":"Cabozantinib","route":"/drugs/cabozantinib/"},{"id":"crizotinib","kind":"drug","name":"Crizotinib","route":"/drugs/crizotinib/"}]}}