{"entity":{"id":"rona-yaeger","kind":"person","name":"Rona Yaeger","aka":[],"tldr":"New York oncologist who was lead author of the KRYSTAL-1 colorectal report, which showed adagrasib with cetuximab shrinks KRAS G12C-mutant colorectal cancer and led to the combination's approval.","summary":"Rona Yaeger is a gastrointestinal medical oncologist and physician-scientist at Memorial Sloan Kettering Cancer Center. She was first author of the 2023 New England Journal of Medicine report of the KRYSTAL-1 cohorts in which adagrasib alone and with cetuximab produced responses in heavily pretreated KRAS G12C-mutant metastatic colorectal cancer, the basis of the combination's accelerated approval. Her laboratory studies mechanisms of resistance to RAS and BRAF inhibitors.","asOf":"2026-09-18","links":[],"tags":["colorectal","targeted-therapy","trialist"],"related":[],"cancers":["kras-g12c-colorectal","braf-v600e-colorectal","colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":["mskcc"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":["paper-krystal-1-crc-yaeger-nejm-2023"],"journals":[],"dependsOn":[],"notes":[],"role":"Gastrointestinal medical oncologist, Memorial Sloan Kettering Cancer Center","institutionId":"mskcc","specialisms":["KRAS G12C colorectal cancer","BRAF-mutant colorectal cancer","Resistance to targeted therapy"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Yaeger%5BAuthor%5D"}],"papers":[]},"route":"/people/rona-yaeger/","neighbours":{"cancer":[{"id":"braf-v600e-colorectal","kind":"cancer","name":"BRAF V600E-mutant colorectal cancer","route":"/cancers/braf-v600e-colorectal/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"kras-g12c-colorectal","kind":"cancer","name":"KRAS G12C-mutant colorectal cancer","route":"/cancers/kras-g12c-colorectal/"}],"institution":[{"id":"mskcc","kind":"institution","name":"Memorial Sloan Kettering Cancer Center","route":"/institutions/mskcc/"}],"paper":[{"id":"paper-krystal-1-crc-yaeger-nejm-2023","kind":"paper","name":"KRYSTAL-1: adagrasib with or without cetuximab in KRAS G12C-mutated colorectal cancer","route":"/key-papers/paper-krystal-1-crc-yaeger-nejm-2023/"}]}}