{"entity":{"id":"rpl10","kind":"target","name":"RPL10","aka":["ribosomal protein L10","Large ribosomal subunit protein uL16","DXS648E","DXS648","FLJ23544","L10","uL16"],"tldr":"RPL10 (Large ribosomal subunit protein uL16) is a gene that drives cell growth when it is altered. The public catalogues list it as a drug target and an oncogene driver, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma, Multiple myeloma, Leukaemia and 1 more.","summary":"Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development.\n\nOpen Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.81, genetic association 0.00, somatic mutation 0.83, clinical 0.11). IntOGen calls it a driver in 2 cohorts (2 activating, 0 loss-of-function), covering Non-Hodgkin Lymphoma, Plasma Cell Myeloma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:10298","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10298"},{"label":"UniProt P27635","url":"https://www.uniprot.org/uniprotkb/P27635/entry"},{"label":"NCBI Gene 6134","url":"https://www.ncbi.nlm.nih.gov/gene/6134"},{"label":"Ensembl ENSG00000147403","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000147403"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["non-hodgkin-lymphoma","multiple-myeloma","leukaemia","all-leukemia"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.19; IntOGen calls it an activating (Act) driver in 2 cohorts. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"RPL10","role":["drug-target","oncogene-driver"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:10298","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10298","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P27635","url":"https://www.uniprot.org/uniprotkb/P27635/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000147403","url":"https://platform.opentargets.org/target/ENSG00000147403/associations","note":"association with cancer (MONDO_0004992) 0.65; per-cancer scores at or above 0.5: acute lymphoblastic leukaemia 0.50, non-Hodgkin lymphoma 0.58, leukaemia 0.52 (GraphQL API, CC0)"},{"label":"IntOGen RPL10","url":"https://www.intogen.org/search?gene=RPL10","note":"driver in 2 cohorts (Act 2, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:10298","ensembl":"ENSG00000147403","uniprot":"P27635","entrez":"6134","biology":"Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Location: Cytoplasm (UniProt). Locus Xq28 (HGNC).","whereFound":["Non-Hodgkin lymphoma: Open Targets association 0.58 with non-Hodgkin lymphoma (MONDO_0018908); IntOGen driver in 1 cohort (NHL)","Multiple myeloma: IntOGen driver in 1 cohort (PCM)","Leukaemia: Open Targets association 0.52 with leukaemia (MONDO_0005059)","Acute lymphoblastic leukaemia: Open Targets association 0.50 with acute lymphoblastic leukaemia (MONDO_0004967)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/rpl10/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"all-leukemia","kind":"cancer","name":"Acute lymphoblastic leukaemia","route":"/cancers/all-leukemia/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"multiple-myeloma","kind":"cancer","name":"Multiple myeloma","route":"/cancers/multiple-myeloma/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"}]}}