{"entity":{"id":"rps27","kind":"target","name":"RPS27","aka":["ribosomal protein S27","Small ribosomal subunit protein eS27","MPS-1","MPS1","S27","eS27"],"tldr":"RPS27 (Small ribosomal subunit protein eS27) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.","summary":"Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Required for proper rRNA processing and maturation of 18S rRNAs.\n\nOpen Targets scores its association with cancer at 0.50 (direct and indirect evidence; datatypes literature 0.91, genetic association 0.09, genetic literature 0.76, clinical 0.11).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:10416","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10416"},{"label":"UniProt P42677","url":"https://www.uniprot.org/uniprotkb/P42677/entry"},{"label":"NCBI Gene 6232","url":"https://www.ncbi.nlm.nih.gov/gene/6232"},{"label":"Ensembl ENSG00000177954","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000177954"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":["mitotic-spindle-checkpoint"],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.11. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"RPS27","role":["drug-target"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:10416","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10416","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P42677","url":"https://www.uniprot.org/uniprotkb/P42677/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000177954","url":"https://platform.opentargets.org/target/ENSG00000177954/associations","note":"association with cancer (MONDO_0004992) 0.50;  (GraphQL API, CC0)"}],"hgnc":"HGNC:10416","ensembl":"ENSG00000177954","uniprot":"P42677","entrez":"6232","biology":"Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Required for proper rRNA processing and maturation of 18S rRNAs. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Location: Cytoplasm; Nucleus, nucleolus (UniProt). Locus 1q21.3 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/rps27/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"pathway":[{"id":"mitotic-spindle-checkpoint","kind":"pathway","name":"Mitosis & the spindle assembly checkpoint","route":"/pathways/mitotic-spindle-checkpoint/"}]}}