{"entity":{"id":"rrm2","kind":"target","name":"RRM2","aka":["ribonucleotide reductase regulatory subunit M2","Ribonucleoside-diphosphate reductase subunit M2","FLJ25102","C2orf48"],"tldr":"RRM2 (Ribonucleoside-diphosphate reductase subunit M2) is an enzyme. The public catalogues list it as a drug target and a biomarker, and an approved or late-stage drug is recorded against it. Tied to Lung cancer, Leukaemia, Breast cancer and 5 more.","summary":"Provides the precursors necessary for DNA synthesis. Catalyses the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signalling.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Gemcitabine. Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.99, genetic association 0.00, clinical 0.99).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:10452","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10452"},{"label":"UniProt P31350","url":"https://www.uniprot.org/uniprotkb/P31350/entry"},{"label":"NCBI Gene 6241","url":"https://www.ncbi.nlm.nih.gov/gene/6241"},{"label":"Ensembl ENSG00000171848","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000171848"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets"],"cancers":["lung-cancer","leukaemia","breast-cancer","non-hodgkin-lymphoma","pancreatic","ovarian","myeloproliferative-neoplasms","mds"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.99; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"RRM2","role":["drug-target","biomarker"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:10452","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10452","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P31350","url":"https://www.uniprot.org/uniprotkb/P31350/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene RRM2","url":"https://civicdb.org/features/5052","note":"1 evidence items, 0 assertions, 1 variants; diseases: Pancreatic Cancer (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000171848","url":"https://platform.opentargets.org/target/ENSG00000171848/associations","note":"association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.62, ovarian cancer 0.59, melanoma 0.58, acute lymphoblastic leukaemia 0.60, B-cell chronic lymphocytic leukaemia 0.59, non-Hodgkin lymphoma 0.60 (GraphQL API, CC0)"}],"hgnc":"HGNC:10452","ensembl":"ENSG00000171848","uniprot":"P31350","entrez":"6241","biology":"Provides the precursors necessary for DNA synthesis. Catalyses the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signalling. Location: Cytoplasm; Nucleus (UniProt). Locus 2p25.1 (HGNC).","whereFound":["Lung cancer: Open Targets association 0.62 with lung cancer (MONDO_0008903)","Leukaemia: Open Targets association 0.62 with leukaemia (MONDO_0005059)","Breast cancer: Open Targets association 0.61 with breast cancer (MONDO_0007254)","Non-Hodgkin lymphoma: Open Targets association 0.60 with non-Hodgkin lymphoma (MONDO_0018908)","Pancreatic ductal adenocarcinoma: CIViC evidence names this disease","Ovarian cancer: Open Targets association 0.59 with ovarian cancer (MONDO_0008170)"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/rrm2/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"mds","kind":"cancer","name":"Myelodysplastic syndromes / neoplasms (MDS)","route":"/cancers/mds/"},{"id":"myeloproliferative-neoplasms","kind":"cancer","name":"Myeloproliferative neoplasms (PV, ET, myelofibrosis)","route":"/cancers/myeloproliferative-neoplasms/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"}]}}