{"entity":{"id":"rrn3","kind":"target","name":"RRN3","aka":["RNA polymerase I transcription factor RRN3","RNA polymerase I-specific transcription initiation factor RRN3","DKFZp566E104","TIF-IA"],"tldr":"RRN3 (RNA polymerase I-specific transcription initiation factor RRN3) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer.","summary":"Required for efficient transcription initiation by RNA polymerase I (Pol I). Required for the formation of the competent pre-initiation complex (PIC).\n\nIntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Colorectal Adenocarcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:30346","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30346"},{"label":"UniProt Q9NYV6","url":"https://www.uniprot.org/uniprotkb/Q9NYV6/entry"},{"label":"NCBI Gene 54700","url":"https://www.ncbi.nlm.nih.gov/gene/54700"},{"label":"Ensembl ENSG00000085721","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000085721"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"RRN3","role":["oncogene-driver"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:30346","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30346","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9NYV6","url":"https://www.uniprot.org/uniprotkb/Q9NYV6/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen RRN3","url":"https://www.intogen.org/search?gene=RRN3","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:30346","ensembl":"ENSG00000085721","uniprot":"Q9NYV6","entrez":"54700","biology":"Required for efficient transcription initiation by RNA polymerase I (Pol I). Required for the formation of the competent pre-initiation complex (PIC). Location: Nucleus, nucleolus (UniProt). Locus 16p13.11 (HGNC).","whereFound":["Colorectal cancer: IntOGen driver in 1 cohort (COADREAD)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/rrn3/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"}]}}