{"entity":{"id":"rsf1","kind":"target","name":"RSF1","aka":["remodeling and spacing factor 1","Remodeling and spacing factor 1","XAP8","RSF-1","p325","HBXAP"],"tldr":"RSF1 (Remodeling and spacing factor 1) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.","summary":"Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex. Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Tamoxifen.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:18118","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18118"},{"label":"UniProt Q96T23","url":"https://www.uniprot.org/uniprotkb/Q96T23/entry"},{"label":"NCBI Gene 51773","url":"https://www.ncbi.nlm.nih.gov/gene/51773"},{"label":"Ensembl ENSG00000048649","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000048649"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["breast-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"RSF1","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:18118","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18118","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q96T23","url":"https://www.uniprot.org/uniprotkb/Q96T23/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene RSF1","url":"https://civicdb.org/features/12121","note":"1 evidence items, 0 assertions, 1 variants; diseases: Breast Cancer (GraphQL API, CC0)"}],"hgnc":"HGNC:18118","ensembl":"ENSG00000048649","uniprot":"Q96T23","entrez":"51773","biology":"Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex. Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively. The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex. The complexes do not have the ability to slide mononucleosomes to the centre of a DNA template. Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. Location: Nucleus (UniProt). Locus 11q14.1 (HGNC).","whereFound":["Breast cancer: CIViC evidence names this disease"],"targetClass":"transcription","prevalence":[]},"route":"/targets/rsf1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"}]}}