{"entity":{"id":"runx1t1","kind":"target","name":"RUNX1T1","aka":["RUNX1 partner transcriptional co-repressor 1","MTG8","ZMYND2","AML1T1","CBFA2T1"],"tldr":"RUNX1T1 (RUNX1 partner transcriptional co-repressor 1) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Lung cancer, Leukaemia, Hepatocellular carcinoma and 5 more.","summary":"Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Can repress the expression of MMP7 in a ZBTB33-dependent manner. Can repress transactivation mediated by TCF12.\n\nOpen Targets scores its association with cancer at 0.69 (direct and indirect evidence; datatypes literature 0.99, animal model 0.30, genetic association 0.32, somatic mutation 0.87). IntOGen calls it a driver in 7 cohorts (4 activating, 3 loss-of-function), covering Hepatocellular Carcinoma, Low-Grade Glioma, NOS, Lung Squamous Cell Carcinoma, Melanoma, Prostate Adenocarcinoma, Small Cell Lung Cancer.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:1535","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1535"},{"label":"UniProt Q06455","url":"https://www.uniprot.org/uniprotkb/Q06455/entry"},{"label":"NCBI Gene 862","url":"https://www.ncbi.nlm.nih.gov/gene/862"},{"label":"Ensembl ENSG00000079102","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000079102"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["lung-cancer","leukaemia","hcc","prostate","skin-cancer","breast-cancer","myeloproliferative-neoplasms","non-hodgkin-lymphoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 4 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 3 cohorts; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate.","Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Low-Grade Glioma, NOS."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"RUNX1T1","role":["oncogene-driver","tumour-suppressor","fusion-partner"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:1535","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1535","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q06455","url":"https://www.uniprot.org/uniprotkb/Q06455/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000079102","url":"https://platform.opentargets.org/target/ENSG00000079102/associations","note":"association with cancer (MONDO_0004992) 0.69; per-cancer scores at or above 0.5: melanoma 0.59, acute myeloid leukaemia 0.51, non-Hodgkin lymphoma 0.52, skin cancer 0.55, myeloproliferative neoplasm 0.52, breast cancer 0.54 (GraphQL API, CC0)"},{"label":"IntOGen RUNX1T1","url":"https://www.intogen.org/search?gene=RUNX1T1","note":"driver in 7 cohorts (Act 4, LoF 3); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:1535","ensembl":"ENSG00000079102","uniprot":"Q06455","entrez":"862","biology":"Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Can repress the expression of MMP7 in a ZBTB33-dependent manner. Can repress transactivation mediated by TCF12. Acts as a negative regulator of adipogenesis. The AML1-MTG8/ETO fusion protein frequently found in leukaemic cells is involved in leukemogenesis and contributes to haematopoietic stem/progenitor cell self-renewal. Location: Nucleus (UniProt). Locus 8q21.3 (HGNC).","whereFound":["Lung cancer: Open Targets association 0.58 with lung cancer (MONDO_0008903)","Leukaemia: Open Targets association 0.57 with leukaemia (MONDO_0005059)","Hepatocellular carcinoma: IntOGen driver in 1 cohort (HCC)","Prostate cancer: IntOGen driver in 1 cohort (PRAD)","Skin cancer: Open Targets association 0.55 with skin cancer (MONDO_0002898)","Breast cancer: Open Targets association 0.54 with breast cancer (MONDO_0007254)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/runx1t1/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"myeloproliferative-neoplasms","kind":"cancer","name":"Myeloproliferative neoplasms (PV, ET, myelofibrosis)","route":"/cancers/myeloproliferative-neoplasms/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}