{"entity":{"id":"samd9","kind":"target","name":"SAMD9","aka":["sterile alpha motif domain containing 9","Sterile alpha motif domain-containing protein 9","KIAA2004","FLJ20073","C7orf5"],"tldr":"SAMD9 (Sterile alpha motif domain-containing protein 9) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Myelodysplastic syndromes / neoplasms.","summary":"Double-stranded nucleic acid binding that acts as an antiviral factor by playing an essential role in the formation of cytoplasmic antiviral granules. May play a role in the inflammatory response to tissue injury and the control of extra-osseous calcification, acting as a downstream target of TNF signalling. Involved in the regulation of EGR1, in coordination with RGL2.\n\n","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:1348","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1348"},{"label":"UniProt Q5K651","url":"https://www.uniprot.org/uniprotkb/Q5K651/entry"},{"label":"NCBI Gene 54809","url":"https://www.ncbi.nlm.nih.gov/gene/54809"},{"label":"Ensembl ENSG00000205413","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000205413"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["mds"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SAMD9","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:1348","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1348","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q5K651","url":"https://www.uniprot.org/uniprotkb/Q5K651/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000205413","url":"https://platform.opentargets.org/target/ENSG00000205413/associations","note":"per-cancer scores at or above 0.5: myelodysplastic syndrome 0.66 (GraphQL API, CC0)"}],"hgnc":"HGNC:1348","ensembl":"ENSG00000205413","uniprot":"Q5K651","entrez":"54809","biology":"Double-stranded nucleic acid binding that acts as an antiviral factor by playing an essential role in the formation of cytoplasmic antiviral granules. May play a role in the inflammatory response to tissue injury and the control of extra-osseous calcification, acting as a downstream target of TNF signalling. Involved in the regulation of EGR1, in coordination with RGL2. May be involved in endosome fusion. Location: Cytoplasm (UniProt). Locus 7q21.2 (HGNC).","whereFound":["Myelodysplastic syndromes / neoplasms: Open Targets association 0.66 with myelodysplastic syndrome (MONDO_0018881)"],"targetClass":"other","prevalence":[]},"route":"/targets/samd9/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"mds","kind":"cancer","name":"Myelodysplastic syndromes / neoplasms (MDS)","route":"/cancers/mds/"}]}}