{"entity":{"id":"samd9l","kind":"target","name":"SAMD9L","aka":["sterile alpha motif domain containing 9 like","Sterile alpha motif domain-containing protein 9-like","KIAA2005","FLJ39885","C7orf6"],"tldr":"SAMD9L (Sterile alpha motif domain-containing protein 9-like) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Myelodysplastic syndromes / neoplasms.","summary":"May be involved in endosome fusion. Mediates down-regulation of growth factor signalling via internalisation of growth factor receptors.\n\nOpen Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.79, animal model 0.58, genetic association 0.19, genetic literature 0.76).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:1349","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1349"},{"label":"UniProt Q8IVG5","url":"https://www.uniprot.org/uniprotkb/Q8IVG5/entry"},{"label":"NCBI Gene 219285","url":"https://www.ncbi.nlm.nih.gov/gene/219285"},{"label":"Ensembl ENSG00000177409","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000177409"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["mds"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SAMD9L","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:1349","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1349","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q8IVG5","url":"https://www.uniprot.org/uniprotkb/Q8IVG5/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000177409","url":"https://platform.opentargets.org/target/ENSG00000177409/associations","note":"association with cancer (MONDO_0004992) 0.51; per-cancer scores at or above 0.5: myelodysplastic syndrome 0.69 (GraphQL API, CC0)"}],"hgnc":"HGNC:1349","ensembl":"ENSG00000177409","uniprot":"Q8IVG5","entrez":"219285","biology":"May be involved in endosome fusion. Mediates down-regulation of growth factor signalling via internalisation of growth factor receptors. Location: Early endosome; Mitochondrion (UniProt). Locus 7q21.2 (HGNC).","whereFound":["Myelodysplastic syndromes / neoplasms: Open Targets association 0.69 with myelodysplastic syndrome (MONDO_0018881)"],"targetClass":"other","prevalence":[]},"route":"/targets/samd9l/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"mds","kind":"cancer","name":"Myelodysplastic syndromes / neoplasms (MDS)","route":"/cancers/mds/"}]}}