{"entity":{"id":"samuraciclib","kind":"drug","name":"Samuraciclib","aka":["ICEC0942","CT7001"],"tldr":"Samuraciclib is an oral cdk inhibitor from Pfizer, in registered phase 2 trials for metastatic cancer, HR-positive / HER2-negative breast cancer.","summary":"Samuraciclib is listed on ClinicalTrials.gov as an intervention in 2 registered phase 2 trials sponsored by Pfizer and Hoffmann-La Roche, in metastatic cancer, HR-positive / HER2-negative breast cancer. A cyclin-dependent kinase inhibitor: the name stem -ciclib marks a small molecule that stops the cell-cycle kinases tumour cells rely on to divide. OnCo records the agent from the registry alone; approvals, results and the sponsor's own description will follow as they are published.","status":"phase-2","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov: trials of Samuraciclib","url":"https://clinicaltrials.gov/search?intr=Samuraciclib"}],"tags":["pipeline","ctgov-ingest","registry-only"],"related":[],"cancers":["metastatic-cancer","breast-hr-positive"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":["pfizer","flatiron-health"],"institutions":[],"pathways":[],"terms":[],"trials":["nct06125522","nct04802759"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"provenance":{"editedBy":"OnCo ingestion (ClinicalTrials.gov v2, registry-only)","editedOn":"2026-09-16"},"modality":"Oral CDK inhibitor","mechanism":"A cyclin-dependent kinase inhibitor: the name stem -ciclib marks a small molecule that stops the cell-cycle kinases tumour cells rely on to divide.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/samuraciclib/","neighbours":{"cancer":[{"id":"breast-hr-positive","kind":"cancer","name":"HR-positive / HER2-negative breast cancer","route":"/cancers/breast-hr-positive/"},{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"}],"company":[{"id":"flatiron-health","kind":"company","name":"Flatiron Health (Roche)","route":"/companies/flatiron-health/"},{"id":"pfizer","kind":"company","name":"Pfizer (incl. Seagen)","route":"/companies/pfizer/"}],"trial":[{"id":"nct04802759","kind":"trial","name":"A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Participants With Breast Cancer","route":"/trials/nct04802759/"},{"id":"nct06125522","kind":"trial","name":"TACTIVE-U: A Study to Learn About the Study Medicine (Vepdegestrant) When Given With Other Medicines in People With Advanced or Metastatic Breast Cancer. (Sub-Study C)","route":"/trials/nct06125522/"}]}}