{"entity":{"id":"sarah-leary","kind":"person","name":"Sarah E. S. Leary","aka":[],"tldr":"Seattle paediatric neuro-oncologist who led COG ACNS0332, the trial that found adding carboplatin to radiotherapy improves survival in children with high-risk group 3 medulloblastoma but isotretinoin does not help.","summary":"Sarah Leary is a paediatric neuro-oncologist at Seattle Children's Hospital and a leader of the Children's Oncology Group brain tumour committee. She was first author of the 2021 JAMA Oncology report of ACNS0332, the randomised trial in high-risk medulloblastoma in which carboplatin given with radiotherapy improved event-free survival in group 3 tumours, while maintenance isotretinoin did not improve outcomes and was stopped early.","asOf":"2026-09-18","links":[],"tags":["paediatric","brain","trialist"],"related":[],"cancers":["medulloblastoma-group-3-4","medulloblastoma","childhood-cancers"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":["seattle-childrens"],"pathways":[],"terms":[],"trials":["acns0332"],"people":[],"bottlenecks":[],"keyPapers":["paper-acns0332-leary-jama-oncol-2021"],"journals":[],"dependsOn":[],"notes":[],"role":"Paediatric neuro-oncologist, Seattle Children's Hospital","institutionId":"seattle-childrens","specialisms":["Medulloblastoma","Paediatric brain tumours","Children's Oncology Group trials"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Leary%5BAuthor%5D"}],"papers":[]},"route":"/people/sarah-leary/","neighbours":{"cancer":[{"id":"childhood-cancers","kind":"cancer","name":"Childhood cancers (all types)","route":"/cancers/childhood-cancers/"},{"id":"medulloblastoma-group-3-4","kind":"cancer","name":"Group 3 and group 4 medulloblastoma (non-WNT/non-SHH)","route":"/cancers/medulloblastoma-group-3-4/"},{"id":"medulloblastoma","kind":"cancer","name":"Medulloblastoma","route":"/cancers/medulloblastoma/"}],"institution":[{"id":"seattle-childrens","kind":"institution","name":"Seattle Children's Hospital","route":"/institutions/seattle-childrens/"}],"trial":[{"id":"acns0332","kind":"trial","name":"COG ACNS0332","route":"/trials/acns0332/"}],"paper":[{"id":"paper-acns0332-leary-jama-oncol-2021","kind":"paper","name":"ACNS0332: carboplatin during radiotherapy and isotretinoin maintenance in high-risk medulloblastoma","route":"/key-papers/paper-acns0332-leary-jama-oncol-2021/"}]}}