{"entity":{"id":"sbds","kind":"target","name":"SBDS","aka":["SBDS ribosome maturation factor","Ribosome maturation protein SBDS","CGI-97","FLJ10917","SDO1"],"tldr":"SBDS (Ribosome maturation protein SBDS) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia, Myeloproliferative neoplasms and Acute myeloid leukaemia.","summary":"Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis.\n\nOpen Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.75, genetic association 0.00, somatic mutation 0.74, genetic literature 0.87).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:19440","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:19440"},{"label":"UniProt Q9Y3A5","url":"https://www.uniprot.org/uniprotkb/Q9Y3A5/entry"},{"label":"NCBI Gene 51119","url":"https://www.ncbi.nlm.nih.gov/gene/51119"},{"label":"Ensembl ENSG00000126524","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000126524"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["leukaemia","myeloproliferative-neoplasms","aml"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SBDS","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:19440","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:19440","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9Y3A5","url":"https://www.uniprot.org/uniprotkb/Q9Y3A5/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000126524","url":"https://platform.opentargets.org/target/ENSG00000126524/associations","note":"association with cancer (MONDO_0004992) 0.65; per-cancer scores at or above 0.5: acute myeloid leukaemia 0.60, myeloproliferative neoplasm 0.60, leukaemia 0.62 (GraphQL API, CC0)"}],"hgnc":"HGNC:19440","ensembl":"ENSG00000126524","uniprot":"Q9Y3A5","entrez":"51119","biology":"Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation. Location: Cytoplasm; Nucleus, nucleolus; Nucleus, nucleoplasm; Cytoplasm, cytoskeleton, spindle (UniProt). Locus 7q11.21 (HGNC).","whereFound":["Leukaemia: Open Targets association 0.62 with leukaemia (MONDO_0005059)","Myeloproliferative neoplasms: Open Targets association 0.60 with myeloproliferative neoplasm (MONDO_0020076)","Acute myeloid leukaemia: Open Targets association 0.60 with acute myeloid leukaemia (MONDO_0018874)"],"targetClass":"other","prevalence":[]},"route":"/targets/sbds/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"aml","kind":"cancer","name":"Acute myeloid leukaemia","route":"/cancers/aml/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"myeloproliferative-neoplasms","kind":"cancer","name":"Myeloproliferative neoplasms (PV, ET, myelofibrosis)","route":"/cancers/myeloproliferative-neoplasms/"}]}}