{"entity":{"id":"scc-after","kind":"trial","name":"SCC-AFTER","aka":["Adjuvant radiotherapy in patients with high-risk primary cutaneous Squamous Cell Carcinoma AFTER surgery","ISRCTN54806122"],"tldr":"The trial testing a thing the NHS already does without evidence: giving radiotherapy after surgery for a high-risk squamous cell carcinoma, to stop it coming back.","summary":"Adjuvant radiotherapy after excision of a high-risk cutaneous squamous cell carcinoma is widely offered in the UK and has never been tested in a randomised trial. SCC-AFTER, sponsored by Cardiff University with a target of 840 participants and a registered end date of 1 January 2031, is the trial. Together with SPOT-IT and EXCISE it makes Cardiff the centre of British keratinocyte cancer trials, which is itself worth noticing: the commonest cancers in the country have almost no randomised evidence base, and most of what is being built is being built in Wales.","status":"recruiting","asOf":"2026-09-25","links":[{"label":"ISRCTN54806122","url":"https://www.isrctn.com/ISRCTN54806122"}],"tags":["uk","skin","radiotherapy","recruiting"],"related":[],"cancers":["cutaneous-scc","skin-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"ISRCTN54806122","phase":"3","setting":"Open-label multicentre two-arm phase 3 randomised trial of adjuvant radiotherapy against no adjuvant radiotherapy after surgery for high-risk primary cutaneous squamous cell carcinoma; registered end date 1 January 2031","sponsor":"Cardiff University","enrolled":840,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/scc-after/","neighbours":{"cancer":[{"id":"cutaneous-scc","kind":"cancer","name":"Cutaneous squamous cell carcinoma","route":"/cancers/cutaneous-scc/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}],"institution":[{"id":"velindre-cardiff","kind":"institution","name":"Velindre Cancer Centre","route":"/institutions/velindre-cardiff/"}]}}