{"entity":{"id":"scn10a","kind":"target","name":"SCN10A","aka":["sodium voltage-gated channel alpha subunit 10","Sodium channel protein type 10 subunit alpha","Nav1.8","hPN3","PN3"],"tldr":"SCN10A (Sodium channel protein type 10 subunit alpha) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.","summary":"Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms.\n\nOpen Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.69, genetic association 0.00, clinical 0.86).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:10582","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10582"},{"label":"UniProt Q9Y5Y9","url":"https://www.uniprot.org/uniprotkb/Q9Y5Y9/entry"},{"label":"NCBI Gene 6336","url":"https://www.ncbi.nlm.nih.gov/gene/6336"},{"label":"Ensembl ENSG00000185313","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000185313"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.86. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SCN10A","role":["drug-target"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:10582","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10582","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9Y5Y9","url":"https://www.uniprot.org/uniprotkb/Q9Y5Y9/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000185313","url":"https://platform.opentargets.org/target/ENSG00000185313/associations","note":"association with cancer (MONDO_0004992) 0.54;  (GraphQL API, CC0)"}],"hgnc":"HGNC:10582","ensembl":"ENSG00000185313","uniprot":"Q9Y5Y9","entrez":"6336","biology":"Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms. Location: Cell membrane (UniProt). Locus 3p22.2 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/scn10a/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}