{"entity":{"id":"scn2a","kind":"target","name":"SCN2A","aka":["sodium voltage-gated channel alpha subunit 2","Sodium channel protein type 2 subunit alpha","Nav1.2","HBSCII","HBSCI","SCN2A1","SCN2A2"],"tldr":"SCN2A (Sodium channel protein type 2 subunit alpha) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.","summary":"Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Implicated in the regulation of hippocampal replay occurring within sharp wave ripples (SPW-R) important for memory.\n\nOpen Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.41, genetic association 0.21, clinical 0.86).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:10588","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10588"},{"label":"UniProt Q99250","url":"https://www.uniprot.org/uniprotkb/Q99250/entry"},{"label":"NCBI Gene 6326","url":"https://www.ncbi.nlm.nih.gov/gene/6326"},{"label":"Ensembl ENSG00000136531","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000136531"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.86. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SCN2A","role":["drug-target"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:10588","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10588","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q99250","url":"https://www.uniprot.org/uniprotkb/Q99250/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000136531","url":"https://platform.opentargets.org/target/ENSG00000136531/associations","note":"association with cancer (MONDO_0004992) 0.57;  (GraphQL API, CC0)"}],"hgnc":"HGNC:10588","ensembl":"ENSG00000136531","uniprot":"Q99250","entrez":"6326","biology":"Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Implicated in the regulation of hippocampal replay occurring within sharp wave ripples (SPW-R) important for memory. Location: Cell membrane (UniProt). Locus 2q24.3 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/scn2a/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}