{"entity":{"id":"scn8a","kind":"target","name":"SCN8A","aka":["sodium voltage-gated channel alpha subunit 8","Sodium channel protein type 8 subunit alpha","Nav1.6","NaCh6","PN4","CerIII"],"tldr":"SCN8A (Sodium channel protein type 8 subunit alpha) is a gene. The public catalogues list it as a drug target and a biomarker, and an approved or late-stage drug is recorded against it. Tied to Non-small-cell lung cancer.","summary":"Pore-forming subunit of a voltage-gated sodium channel complex assuming opened or closed conformations in response to the voltage difference across membranes and through which sodium ions selectively pass along their electrochemical gradient. Contributes to neuronal excitability by regulating action potential threshold and propagation. More specifically expressed in non-neuronal cells, could play a role in sodium release from intracellular compartments and participate in the control of podosomes formation and macrophages adhesion and movement.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Pembrolizumab. Open Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.91, animal model 0.57, genetic association 0.00, clinical 0.86).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:10596","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10596"},{"label":"UniProt Q9UQD0","url":"https://www.uniprot.org/uniprotkb/Q9UQD0/entry"},{"label":"NCBI Gene 6334","url":"https://www.ncbi.nlm.nih.gov/gene/6334"},{"label":"Ensembl ENSG00000196876","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000196876"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets"],"cancers":["nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.86; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SCN8A","role":["drug-target","biomarker"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:10596","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10596","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9UQD0","url":"https://www.uniprot.org/uniprotkb/Q9UQD0/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene SCN8A","url":"https://civicdb.org/features/5128","note":"1 evidence items, 0 assertions, 1 variants; diseases: Lung Adenocarcinoma (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000196876","url":"https://platform.opentargets.org/target/ENSG00000196876/associations","note":"association with cancer (MONDO_0004992) 0.56;  (GraphQL API, CC0)"}],"hgnc":"HGNC:10596","ensembl":"ENSG00000196876","uniprot":"Q9UQD0","entrez":"6334","biology":"Pore-forming subunit of a voltage-gated sodium channel complex assuming opened or closed conformations in response to the voltage difference across membranes and through which sodium ions selectively pass along their electrochemical gradient. Contributes to neuronal excitability by regulating action potential threshold and propagation. More specifically expressed in non-neuronal cells, could play a role in sodium release from intracellular compartments and participate in the control of podosomes formation and macrophages adhesion and movement. Location: Cell membrane; Cell projection, axon; Cytoplasmic vesicle; Cell projection, podosome (UniProt). Locus 12q13.13 (HGNC).","whereFound":["Non-small-cell lung cancer: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/scn8a/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}]}}