{"entity":{"id":"scn9a","kind":"target","name":"SCN9A","aka":["sodium voltage-gated channel alpha subunit 9","Sodium channel protein type 9 subunit alpha","Nav1.7","PN1","NE-NA"],"tldr":"SCN9A (Sodium channel protein type 9 subunit alpha) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.","summary":"Pore-forming subunit of Nav1.7, a voltage-gated sodium (Nav) channel that directly mediates the depolarising phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient.\n\nOpen Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.87, genetic association 0.00, clinical 0.86).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:10597","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10597"},{"label":"UniProt Q15858","url":"https://www.uniprot.org/uniprotkb/Q15858/entry"},{"label":"NCBI Gene 6335","url":"https://www.ncbi.nlm.nih.gov/gene/6335"},{"label":"Ensembl ENSG00000169432","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000169432"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.86. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SCN9A","role":["drug-target"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:10597","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10597","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q15858","url":"https://www.uniprot.org/uniprotkb/Q15858/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000169432","url":"https://platform.opentargets.org/target/ENSG00000169432/associations","note":"association with cancer (MONDO_0004992) 0.55;  (GraphQL API, CC0)"}],"hgnc":"HGNC:10597","ensembl":"ENSG00000169432","uniprot":"Q15858","entrez":"6335","biology":"Pore-forming subunit of Nav1.7, a voltage-gated sodium (Nav) channel that directly mediates the depolarising phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarisation, initiating the propagation of electrical signals throughout cells and tissues. Nav1.7 plays a crucial role in controlling the excitability and action potential propagation from nociceptor neurons, thereby contributing to the sensory perception of pain. Location: Cell membrane; Cell projection, neuron projection; Cell projection, axon (UniProt). Locus 2q24.3 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/scn9a/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}