{"entity":{"id":"sdcbp","kind":"target","name":"SDCBP","aka":["syndecan binding protein","Syntenin-1","MDA-9","SDCBP1"],"tldr":"SDCBP (Syntenin-1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Head and neck squamous cell carcinoma.","summary":"Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis. Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signalling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalisation and degradation of TGFR1.\n\nIntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Head and Neck Squamous Cell Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:10662","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10662"},{"label":"UniProt O00560","url":"https://www.uniprot.org/uniprotkb/O00560/entry"},{"label":"NCBI Gene 6386","url":"https://www.ncbi.nlm.nih.gov/gene/6386"},{"label":"Ensembl ENSG00000137575","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000137575"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["head-and-neck"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SDCBP","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:10662","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10662","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O00560","url":"https://www.uniprot.org/uniprotkb/O00560/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen SDCBP","url":"https://www.intogen.org/search?gene=SDCBP","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:10662","ensembl":"ENSG00000137575","uniprot":"O00560","entrez":"6386","biology":"Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis. Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signalling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalisation and degradation of TGFR1. In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis. Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signalling components. Location: Cell junction, focal adhesion; Cell junction, adherens junction; Cell membrane; Endoplasmic reticulum membrane (UniProt). Locus 8q12.1 (HGNC).","whereFound":["Head and neck squamous cell carcinoma: IntOGen driver in 1 cohort (HNSC)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/sdcbp/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"}]}}