{"entity":{"id":"sdccag8","kind":"target","name":"SDCCAG8","aka":["SHH signaling and ciliogenesis regulator SDCCAG8","Serologically defined colon cancer antigen 8","NY-CO-8","CCCAP","SLSN7","NPHP10","BBS16"],"tldr":"SDCCAG8 (Serologically defined colon cancer antigen 8) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer.","summary":"Plays a role in the establishment of cell polarity and epithelial lumen formation. Also plays an essential role in ciliogenesis and subsequent Hedgehog signalling pathway that requires the presence of intact primary cilia for pathway activation. Mechanistically, interacts with and mediates RABEP2 centrosomal localisation which is critical for ciliogenesis.\n\nOpen Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.68, animal model 0.44, genetic association 0.70).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:10671","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10671"},{"label":"UniProt Q86SQ7","url":"https://www.uniprot.org/uniprotkb/Q86SQ7/entry"},{"label":"NCBI Gene 10806","url":"https://www.ncbi.nlm.nih.gov/gene/10806"},{"label":"Ensembl ENSG00000054282","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000054282"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["thyroid"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SDCCAG8","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:10671","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10671","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q86SQ7","url":"https://www.uniprot.org/uniprotkb/Q86SQ7/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000054282","url":"https://platform.opentargets.org/target/ENSG00000054282/associations","note":"association with cancer (MONDO_0004992) 0.56; per-cancer scores at or above 0.5: thyroid cancer 0.53 (GraphQL API, CC0)"}],"hgnc":"HGNC:10671","ensembl":"ENSG00000054282","uniprot":"Q86SQ7","entrez":"10806","biology":"Plays a role in the establishment of cell polarity and epithelial lumen formation. Also plays an essential role in ciliogenesis and subsequent Hedgehog signalling pathway that requires the presence of intact primary cilia for pathway activation. Mechanistically, interacts with and mediates RABEP2 centrosomal localisation which is critical for ciliogenesis. Location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasm, cytoskeleton, cilium basal body; Cell junction (UniProt). Locus 1q43-q44 (HGNC).","whereFound":["Thyroid cancer: Open Targets association 0.53 with thyroid cancer (MONDO_0002108)"],"targetClass":"other","prevalence":[]},"route":"/targets/sdccag8/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"thyroid","kind":"cancer","name":"Thyroid cancer","route":"/cancers/thyroid/"}]}}