{"entity":{"id":"sdhb","kind":"target","name":"SDHB","aka":["succinate dehydrogenase complex iron sulfur subunit B","Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial","SDH1"],"tldr":"SDHB (Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Neuroendocrine tumours, Breast cancer and Gastrointestinal stromal tumour.","summary":"Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidises malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerised into keto-oxaloacetate.\n\nCIViC holds 3 clinical evidence items and 0 assertions across 4 variants, naming Vandetanib and Metformin. Open Targets scores its association with cancer at 0.70 (direct and indirect evidence; datatypes literature 0.98, affected pathway 0.32, genetic association 0.61, somatic mutation 0.96).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:10681","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10681"},{"label":"UniProt P21912","url":"https://www.uniprot.org/uniprotkb/P21912/entry"},{"label":"NCBI Gene 6390","url":"https://www.ncbi.nlm.nih.gov/gene/6390"},{"label":"Ensembl ENSG00000117118","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000117118"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets"],"cancers":["neuroendocrine","breast-cancer","gist"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 3 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate.","Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Paraganglioma; Hereditary Renal Cell Carcinoma."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SDHB","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:10681","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10681","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P21912","url":"https://www.uniprot.org/uniprotkb/P21912/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene SDHB","url":"https://civicdb.org/features/5177","note":"3 evidence items, 0 assertions, 4 variants; diseases: Paraganglioma, Hereditary Renal Cell Carcinoma (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000117118","url":"https://platform.opentargets.org/target/ENSG00000117118/associations","note":"association with cancer (MONDO_0004992) 0.70; per-cancer scores at or above 0.5: neuroendocrine neoplasm 0.88, gastrointestinal stromal tumour 0.75, breast cancer 0.54 (GraphQL API, CC0)"}],"hgnc":"HGNC:10681","ensembl":"ENSG00000117118","uniprot":"P21912","entrez":"6390","biology":"Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidises malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerised into keto-oxaloacetate. Location: Mitochondrion inner membrane (UniProt). Locus 1p36.13 (HGNC).","whereFound":["Neuroendocrine tumours: Open Targets association 0.88 with neuroendocrine neoplasm (MONDO_0019496)","Breast cancer: Open Targets association 0.54 with breast cancer (MONDO_0007254)","Gastrointestinal stromal tumour: Open Targets association 0.75 with gastrointestinal stromal tumour (MONDO_0011719)"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/sdhb/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"gist","kind":"cancer","name":"Gastrointestinal stromal tumour (GIST)","route":"/cancers/gist/"},{"id":"neuroendocrine","kind":"cancer","name":"Neuroendocrine tumours","route":"/cancers/neuroendocrine/"}]}}