{"entity":{"id":"sdhc","kind":"target","name":"SDHC","aka":["succinate dehydrogenase complex subunit C","Succinate dehydrogenase cytochrome b560 subunit, mitochondrial","CYB560","cybL","PGL3"],"tldr":"SDHC (Succinate dehydrogenase cytochrome b560 subunit, mitochondrial) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Neuroendocrine tumours, Breast cancer, Colorectal cancer and 1 more.","summary":"Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidises malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerised into keto-oxaloacetate.\n\nOpen Targets scores its association with cancer at 0.75 (direct and indirect evidence; datatypes genetic literature 0.79, literature 0.91, genetic association 0.43, somatic mutation 0.97, animal model 0.38).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:10682","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10682"},{"label":"UniProt Q99643","url":"https://www.uniprot.org/uniprotkb/Q99643/entry"},{"label":"NCBI Gene 6391","url":"https://www.ncbi.nlm.nih.gov/gene/6391"},{"label":"Ensembl ENSG00000143252","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000143252"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["neuroendocrine","breast-cancer","colorectal","gist"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SDHC","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:10682","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10682","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q99643","url":"https://www.uniprot.org/uniprotkb/Q99643/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000143252","url":"https://platform.opentargets.org/target/ENSG00000143252/associations","note":"association with cancer (MONDO_0004992) 0.75; per-cancer scores at or above 0.5: colorectal cancer 0.50, neuroendocrine neoplasm 0.83, gastrointestinal stromal tumour 0.72, breast cancer 0.54 (GraphQL API, CC0)"}],"hgnc":"HGNC:10682","ensembl":"ENSG00000143252","uniprot":"Q99643","entrez":"6391","biology":"Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidises malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerised into keto-oxaloacetate. Location: Mitochondrion inner membrane (UniProt). Locus 1q23.3 (HGNC).","whereFound":["Neuroendocrine tumours: Open Targets association 0.83 with neuroendocrine neoplasm (MONDO_0019496)","Breast cancer: Open Targets association 0.54 with breast cancer (MONDO_0007254)","Colorectal cancer: Open Targets association 0.50 with colorectal cancer (MONDO_0005575)","Gastrointestinal stromal tumour: Open Targets association 0.72 with gastrointestinal stromal tumour (MONDO_0011719)"],"targetClass":"other","prevalence":[]},"route":"/targets/sdhc/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"gist","kind":"cancer","name":"Gastrointestinal stromal tumour (GIST)","route":"/cancers/gist/"},{"id":"neuroendocrine","kind":"cancer","name":"Neuroendocrine tumours","route":"/cancers/neuroendocrine/"}]}}